Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIKFYVE
  • Mouse genes Pikfyve
  • Rat genes Pikfyve
  • Zfish genes pikfyve
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pikfyve

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	PIKFYVE	IDA		Human	PMID:22621786
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:6450296|PMID:22621786
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:6450304|PMID:11123925
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:3790799|PMID:10419465
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:1321345|PMID:9858586
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	PIKFYVE	IDA		Human	PMID:22621786
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:3790799|PMID:10419465
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:6450304|PMID:11123925
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:6450296|PMID:22621786
Molecular Function	GO:0016301	kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:6450292|PMID:14530284
Molecular Function	GO:0005515	protein binding	PIKFYVE	IPI	UniProtKB:Q06187	Human	PMID:15046600
Molecular Function	GO:0005515	protein binding	PIKFYVE	IPI	UniProtKB:Q92562	Human	PMID:17556371
Molecular Function	GO:0005515	protein binding	PIKFYVE	IPI	UniProtKB:P00533	Human	PMID:17909029
Molecular Function	GO:0005515	protein binding	PIKFYVE	IPI	UniProtKB:Q08AM6	Human	PMID:19037259
Molecular Function	GO:0005515	protein binding	PIKFYVE	IPI	UniProtKB:Q08AM6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIKFYVE	IPI	UniProtKB:Q08AM6	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	Pikfyve	IPI	UniProtKB:Q92562	Mouse	MGI:MGI:3799555|PMID:17556371
Molecular Function	GO:0005515	protein binding	Pikfyve	IPI	UniProtKB:Q7Z6M1	Mouse	MGI:MGI:6450292|PMID:14530284
Molecular Function	GO:0005515	protein binding	Pikfyve	IPI	PR:Q58A65-1	Mouse	PMID:19056739
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pikfyve	IDA		Mouse	MGI:MGI:6450304|PMID:11123925
Molecular Function	GO:0008270	zinc ion binding	Pikfyve	IDA		Mouse	MGI:MGI:1321345|PMID:9858586
Cellular Component	GO:0005911	cell-cell junction	Pikfyve	IDA		Mouse	PMID:23793062
Cellular Component	GO:0031410	cytoplasmic vesicle	Pikfyve	IDA		Mouse	PMID:11112776
Cellular Component	GO:0005829	cytosol	Pikfyve	IDA		Mouse	PMID:11112776
Cellular Component	GO:0031901	early endosome membrane	PIKFYVE	IDA		Human	PMID:16448788
Cellular Component	GO:0031901	early endosome membrane	PIKFYVE	IDA		Human	PMID:16954148
Cellular Component	GO:0031901	early endosome membrane	PIKFYVE	IDA		Human	PMID:30612035
Cellular Component	GO:0010008	endosome membrane	PIKFYVE	IDA		Human	PMID:17556371
Cellular Component	GO:0016020	membrane	pikfyve	IDA		Zfish	PMID:18558518
Cellular Component	GO:0045121	membrane raft	PIKFYVE	IDA		Human	PMID:15046600
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pikfyve	IDA		Mouse	PMID:19056739
Cellular Component	GO:0048471	perinuclear region of cytoplasm	pikfyve	IDA		Zfish	PMID:18558518
Cellular Component	GO:0030670	phagocytic vesicle membrane	PIKFYVE	IDA		Human	PMID:30612035
Cellular Component	GO:0012506	vesicle membrane	Pikfyve	IDA		Mouse	MGI:MGI:1321345|PMID:9858586
Biological Process	GO:1903100	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	Pikfyve	IDA		Mouse	MGI:MGI:6450304|PMID:11123925
Biological Process	GO:1903100	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	Pikfyve	IDA		Mouse	MGI:MGI:6450296|PMID:22621786
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	PIKFYVE	IDA		Human	PMID:30612035
Biological Process	GO:0035556	intracellular signal transduction	Pikfyve	IDA		Mouse	MGI:MGI:1321345|PMID:9858586
Biological Process	GO:0007041	lysosomal transport	pikfyve	IMP	ZFIN:ZDB-GENO-220421-23	Zfish	PMID:33909505
Biological Process	GO:0032438	melanosome organization	PIKFYVE	IDA		Human	PMID:29584722
Biological Process	GO:0032438	melanosome organization	Pikfyve	IMP		Mouse	MGI:MGI:6152906|PMID:29584722
Biological Process	GO:0032288	myelin assembly	Pikfyve	IGI	MGI:MGI:1924366	Mouse	PMID:22028665
Biological Process	GO:0030593	neutrophil chemotaxis	PIKFYVE	IDA		Human	PMID:28779020
Biological Process	GO:0030593	neutrophil chemotaxis	Pikfyve	IDA		Mouse	MGI:MGI:6103777|PMID:28779020
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	Pikfyve	IDA		Mouse	MGI:MGI:6450304|PMID:11123925
Biological Process	GO:0090382	phagosome maturation	PIKFYVE	IDA		Human	PMID:27623384
Biological Process	GO:0090382	phagosome maturation	Pikfyve	IDA		Mouse	MGI:MGI:6436407|PMID:27623384
Biological Process	GO:0090385	phagosome-lysosome fusion	PIKFYVE	IDA		Human	PMID:28779020
Biological Process	GO:0090385	phagosome-lysosome fusion	Pikfyve	IDA		Mouse	MGI:MGI:6103777|PMID:28779020
Biological Process	GO:1904562	phosphatidylinositol 5-phosphate metabolic process	Pikfyve	IDA		Mouse	MGI:MGI:6450296|PMID:22621786
Biological Process	GO:1904562	phosphatidylinositol 5-phosphate metabolic process	Pikfyve	IDA		Mouse	MGI:MGI:6450304|PMID:11123925
Biological Process	GO:0034504	protein localization to nucleus	PIKFYVE	IMP		Human	PMID:17909029
Biological Process	GO:0006612	protein targeting to membrane	Pikfyve	IDA		Mouse	MGI:MGI:6450292|PMID:14530284
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	PIKFYVE	IDA		Human	PMID:32221306
Biological Process	GO:2000785	regulation of autophagosome assembly	PIKFYVE	IMP		Human	PMID:25578879
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	PIKFYVE	IDA		Human	PMID:28779020
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	Pikfyve	IDA		Mouse	MGI:MGI:6103777|PMID:28779020
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	PIKFYVE	IMP		Human	PMID:14551253
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	PIKFYVE	IMP		Human	PMID:16954148

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern