Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIK3R6
  • Mouse genes Pik3r6
  • Rat genes Pik3r6
  • Zfish genes pik3r6a,pik3r6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3r6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Pik3r6	IDA		Mouse	MGI:MGI:3574247|PMID:15797027
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Pik3r6	IDA		Mouse	MGI:MGI:4413485|PMID:19906996
Molecular Function	GO:0005515	protein binding	PIK3R6	IPI	UniProtKB:Q13370	Human	PMID:21393242
Molecular Function	GO:0005515	protein binding	Pik3r6	IPI	UniProtKB:Q9JHG7	Mouse	MGI:MGI:5014454|PMID:21665146
Molecular Function	GO:0005515	protein binding	Pik3r6	IPI	UniProtKB:Q9JHG7	Mouse	MGI:MGI:3574247|PMID:15797027
Molecular Function	GO:0005515	protein binding	Pik3r6	IPI	UniProtKB:P48736|UniProtKB:Q9JHG7	Mouse	MGI:MGI:5514086|PMID:23824069
Cellular Component	GO:0016020	membrane	Pik3r6	IDA		Mouse	MGI:MGI:4413485|PMID:19906996
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3R6	EXP		Human	PMID:10358071
Cellular Component	GO:0005944	phosphatidylinositol 3-kinase complex, class IB	Pik3r6	IDA		Mouse	MGI:MGI:3574247|PMID:15797027
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	PIK3R6	EXP		Human	PMID:10358071
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Pik3r6	IDA		Mouse	MGI:MGI:4413485|PMID:19906996
Biological Process	GO:0045766	positive regulation of angiogenesis	PIK3R6	IMP		Human	PMID:21393242
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Pik3r6	IDA		Mouse	MGI:MGI:4413485|PMID:19906996
Biological Process	GO:0045582	positive regulation of T cell differentiation	Pik3r6	IMP		Mouse	MGI:MGI:3641361|PMID:12707323
Biological Process	GO:0042269	regulation of natural killer cell mediated cytotoxicity	PIK3R6	IDA		Human	PMID:11062502

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern