Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIK3R4
  • Mouse genes Pik3r4
  • Rat genes Pik3r4
  • Zfish genes pik3r4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3r4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:P51149	Human	PMID:14617358
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q14457	Human	PMID:19270696
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q6ZNE5	Human	PMID:19270696
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q92622	Human	PMID:19270696
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q9P2Y5	Human	PMID:19270696
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q14457	Human	PMID:23878393
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q96F24	Human	PMID:24785657
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q96F24	Human	PMID:24849286
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q96F24	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q53EP0-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q96F24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PIK3R4	IPI	UniProtKB:Q96F24	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Pik3r4	IPI	UniProtKB:P23242	Mouse	MGI:MGI:5915435|PMID:24705551
Cellular Component	GO:0005930	axoneme	Pik3r4	IDA		Mouse	MGI:MGI:5527012|PMID:24089209
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PIK3R4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	PIK3R4	IDA		Human	PMID:14617358
Cellular Component	GO:0016020	membrane	PIK3R4	HDA		Human	PMID:19946888
Cellular Component	GO:0015630	microtubule cytoskeleton	PIK3R4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0035032	phosphatidylinositol 3-kinase complex, class III	PIK3R4	IPI		Human	PMID:25490155
Cellular Component	GO:0035032	phosphatidylinositol 3-kinase complex, class III	Pik3r4	IDA		Mouse	MGI:MGI:5619439|PMID:23332761
Biological Process	GO:0097352	autophagosome maturation	PIK3R4	IDA		Human	PMID:10625637
Biological Process	GO:0042149	cellular response to glucose starvation	Pik3r4	IDA		Mouse	MGI:MGI:5619439|PMID:23332761
Biological Process	GO:0045022	early endosome to late endosome transport	PIK3R4	IDA		Human	PMID:14617358
Biological Process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	PIK3R4	IDA		Human	PMID:8999962
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PIK3R4	IDA		Human	PMID:21062745
Biological Process	GO:0006468	protein phosphorylation	PIK3R4	IDA		Human	PMID:8999962
Biological Process	GO:0032801	receptor catabolic process	PIK3R4	IMP		Human	PMID:20643123
Biological Process	GO:0010506	regulation of autophagy	PIK3R4	IDA		Human	PMID:16799551
Biological Process	GO:0032465	regulation of cytokinesis	PIK3R4	IMP		Human	PMID:20643123
Biological Process	GO:0016241	regulation of macroautophagy	PIK3R4	IDA		Human	PMID:10625637

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern