Pik3r4 MGI Mouse Gene Detail - MGI:1922919 - phosphoinositide-3-kinase regulatory subunit 4

Symbol

Pik3r4
Name

phosphoinositide-3-kinase regulatory subunit 4
Synonyms

p150, Vps15

Feature Type

protein coding gene
IDs

MGI:1922919
NCBI Gene: 75669
Gene Overview

MyGene.info: PIK3R4
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:105642995-105687655 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 56.79 cM, cytoband F1
Mapping Data

4 experiments

SNPs within 2kb

627 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922919	protein coding gene	Chr9:105642978-105687657 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035216	protein coding gene	Chr9:107375865-107424739 (+)
A/J	MGP_AJ_G0035196	protein coding gene	Chr9:103511451-103560566 (+)
AKR/J	MGP_AKRJ_G0035128	protein coding gene	Chr9:106090257-106138155 (+)
BALB/cJ	MGP_BALBcJ_G0035189	protein coding gene	Chr9:103201506-103249414 (+)
C3H/HeJ	MGP_C3HHeJ_G0034899	protein coding gene	Chr9:106490023-106538883 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035709	protein coding gene	Chr9:110352035-110396744 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032607	protein coding gene	Chr9:101023002-101073120 (+)
CAST/EiJ	MGP_CASTEiJ_G0034211	protein coding gene	Chr9:106391390-106438301 (+)
CBA/J	MGP_CBAJ_G0034868	protein coding gene	Chr9:114189233-114247155 (+)
DBA/2J	MGP_DBA2J_G0035029	protein coding gene	Chr9:102982007-103030566 (+)
FVB/NJ	MGP_FVBNJ_G0034977	protein coding gene	Chr9:101751929-101801288 (+)
LP/J	MGP_LPJ_G0035105	protein coding gene	Chr9:107596138-107645521 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035016	protein coding gene	Chr9:115890550-115942037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035731	protein coding gene	Chr9:106340626-106389788 (+)
PWK/PhJ	MGP_PWKPhJ_G0033918	protein coding gene	Chr9:103277968-103323469 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033753	protein coding gene	Chr9:106391582-106439405 (+)
WSB/EiJ	MGP_WSBEiJ_G0034331	protein coding gene	Chr9:106219239-106276145 (+)

Human Ortholog

PIK3R4, phosphoinositide-3-kinase regulatory subunit 4

Vertebrate Orthologs

10

Human Ortholog

PIK3R4, phosphoinositide-3-kinase regulatory subunit 4
Orthology source: HomoloGene, HGNC
Synonyms

p150, VPS15
Links

HGNC:8982

NCBI Gene ID: 30849

neXtProt AC: NX_Q99570

UniProt: Q99570
Chr Location

3q22.1; chr3:130678934-130746852 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 24678
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PIK3R4
Gene Tree

Pik3r4

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Phenotype Summary

22 phenotypes from 3 alleles in 7 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit early embryonic lethality before E7.5. Mice homozygous for a conditional allele activated in muscles exhibit symptoms of autophagic vacuolar myopathies.

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All GO Annotations

30
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

640
Tissues

7
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pik3r4

ZFIN pik3r4

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Pik3r4 interacts with 97 markers (Mir7-1, Mir17, Mir22, ...) View All

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All Sequences

65
RefSeq

3
UniProt

6
CCDS

CCDS40753.1

Ensembl

ENSMUSG00000032571 (Evidence)
NCBI Gene

75669

			Length	Strain/Species	Flank
genomic	75669	NCBI Gene Model \| MGI Sequence Detail	44661	C57BL/6J	± kb
transcript	NM_001081309	RefSeq \| MGI Sequence Detail	4884	Not Specified
polypeptide	Q8VD65	UniProt \| EBI \| MGI Sequence Detail	1358	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012727 phosphoinositide 3-kinase regulatory subunit 4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR021133 HEAT, type 2

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR017986 WD40-repeat-containing domain

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 3

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MGI:1196267, MGI:2143428, MGI:2442102

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:258027 Gstrein T, et al., Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018 Feb;21(2):207-217

TSS for Pik3r4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86844	Chr9:105642957-105643036 (+)	2 bp
Tssr86845	Chr9:105658386-105658391 (+)	15,394 bp
Tssr86846	Chr9:105658402-105658426 (+)	15,419 bp
Tssr86847	Chr9:105658435-105658456 (+)	15,451 bp
Tssr86848	Chr9:105658479-105658489 (+)	15,489 bp
Tssr86849	Chr9:105658498-105658505 (+)	15,507 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/19/2020 MGI 6.15