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Pik3r4 Gene Detail
Summary
  • Symbol
    Pik3r4
  • Name
    phosphoinositide-3-kinase regulatory subunit 4
  • Synonyms
    p150, Vps15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922919
    NCBI Gene: 75669
  • Gene Overview
    MyGene.info: PIK3R4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:105642978-105687657 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      44680 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 56.79 cM, cytoband F1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PIK3R4, phosphoinositide-3-kinase regulatory subunit 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3R4, phosphoinositide-3-kinase regulatory subunit 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p150, VPS15
  • Links
    NCBI Gene ID: 30849
    neXtProt AC: NX_Q99570
    UniProt: Q99570

  • Chr Location
    3q22.1; chr3:130678934-130746852 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 24678
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PIK3R4
  • Gene Tree
    Pik3r4
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit earl embryonic lethality before E7.5. Mice homozygous for a conditional allele activated in muscles exhibit symptoms of autophagic vacuolar myopathies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    9
  • Tissues
    7
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000049417 VEGA Gene Model | MGI Sequence Detail 44680 C57BL/6J ±  kb
    transcript OTTMUST00000125980 VEGA | MGI Sequence Detail 4756 Not Applicable  
    polypeptide OTTMUSP00000068172 VEGA | MGI Sequence Detail 1358 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      628 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196267, MGI:2143428, MGI:2442102
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:258027 Gstrein T, et al., Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018 Feb;21(2):207-217
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory