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Pik3r4 Gene Detail
Summary
  • Symbol
    Pik3r4
  • Name
    phosphoinositide-3-kinase regulatory subunit 4
  • Synonyms
    p150, Vps15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922919
    NCBI Gene: 75669
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:105520177-105564856 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 56.79 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    608 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922919
 protein coding gene Chr9:105520156-105564856 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035216
 protein coding gene Chr9:107375865-107424739 (+)
A/J MGP_AJ_G0035196
 protein coding gene Chr9:103511451-103560566 (+)
AKR/J MGP_AKRJ_G0035128
 protein coding gene Chr9:106090257-106138155 (+)
BALB/cJ MGP_BALBcJ_G0035189
 protein coding gene Chr9:103201506-103249414 (+)
C3H/HeJ MGP_C3HHeJ_G0034899
 protein coding gene Chr9:106490023-106538883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035709
 protein coding gene Chr9:110352035-110396744 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032607
 protein coding gene Chr9:101023002-101073120 (+)
CAST/EiJ MGP_CASTEiJ_G0034211
 protein coding gene Chr9:106391390-106438301 (+)
CBA/J MGP_CBAJ_G0034868
 protein coding gene Chr9:114189233-114247155 (+)
DBA/2J MGP_DBA2J_G0035029
 protein coding gene Chr9:102982007-103030566 (+)
FVB/NJ MGP_FVBNJ_G0034977
 protein coding gene Chr9:101751929-101801288 (+)
LP/J MGP_LPJ_G0035105
 protein coding gene Chr9:107596138-107645521 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035016
 protein coding gene Chr9:115890550-115942037 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035731
 protein coding gene Chr9:106340626-106389788 (+)
PWK/PhJ MGP_PWKPhJ_G0033918
 protein coding gene Chr9:103277968-103323469 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033753
 protein coding gene Chr9:106391582-106439405 (+)
WSB/EiJ MGP_WSBEiJ_G0034331
 protein coding gene Chr9:106219239-106276145 (+)



Homology
more
  • Human Ortholog
    PIK3R4, phosphoinositide-3-kinase regulatory subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3R4, phosphoinositide-3-kinase regulatory subunit 4
  • Synonyms
    p150, VPS15
  • Links
    NCBI Gene ID: 30849
    neXtProt AC: NX_Q99570
    UniProt: Q99570

  • Chr Location
    3q22.1; chr3:130678934-130746852 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 7 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early embryonic lethality before E7.5. Mice homozygous for a conditional allele activated in muscles exhibit symptoms of autophagic vacuolar myopathies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    7
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032571 Ensembl Gene Model | MGI Sequence Detail 44680 C57BL/6J ±  kb
    transcript ENSMUST00000065778 Ensembl | MGI Sequence Detail 4711 Not Applicable  
    polypeptide ENSMUSP00000067400 Ensembl | MGI Sequence Detail 1358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196267, MGI:2143428, MGI:2442102
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:274367 Iershov A, et al., The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARalpha. Nat Commun. 2019 Apr 5;10(1):1566
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/23/2022
    MGI 6.20     		The Jackson Laboratory