Pik3r4 MGI Mouse Gene Detail - MGI:1922919 - phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150

Pik3r4 Gene Detail

Symbol

Pik3r4
Name

phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
Synonyms

2210010O15Rik, C730038E05Rik, D9Ertd418e

Feature Type

protein coding gene
IDs

MGI:1922919
NCBI Gene: 75669
Gene Overview

MyGene.info: PIK3R4

Sequence Map

Chr9:105642978-105687657 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

44680 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 56.79 cM, cytoband F1
Mapping Data

4 experiments

Human Ortholog

PIK3R4, phosphoinositide-3-kinase regulatory subunit 4

Vertebrate Orthologs

10

Human Ortholog

PIK3R4, phosphoinositide-3-kinase regulatory subunit 4
Orthology source: HomoloGene, HGNC
Synonyms

p150, VPS15
Links

HGNC:8982

NCBI Gene ID: 30849

neXtProt AC: NX_Q99570
Chr Location

3q22.1; chr3:130678934-130746852 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 24678
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PIK3R4
Gene Tree

Pik3r4

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Phenotype Summary

12 phenotypes from 2 alleles in 3 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a knock-out allele exhibit earl embryonic lethality before E7.5. Mice homozygous for a conditional allele activated in muscles exhibit symptoms of autophagic vacuolar myopathies.

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All GO Annotations

28
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

9
Tissues

7
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase pik3r4

ZFIN pik3r4

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Pik3r4 interacts with 97 markers (Mir7-1, Mir17, Mir22, ...) View All

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All Sequences

64
RefSeq

4
UniProt

6
CCDS

CCDS40753.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000049417	VEGA Gene Model \| MGI Sequence Detail	44680	C57BL/6J	± kb
transcript	OTTMUST00000125980	VEGA \| MGI Sequence Detail	4756	Not Applicable
polypeptide	OTTMUSP00000068172	VEGA \| MGI Sequence Detail	1358	Not Applicable

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SNPs within 2kb

628 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000012727 phosphoinositide 3-kinase regulatory subunit 4
EC

2.7.11.1
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR021133 HEAT, type 2

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR008271 Serine/threonine-protein kinase, active site

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR017986 WD40-repeat-containing domain

IPR015943 WD40/YVTN repeat-like-containing domain

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 3

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MGI:1196267, MGI:2143428, MGI:2442102

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:226982 Nemazanyy I, et al., Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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