Pik3r4 MGI Mouse Gene Detail - MGI:1922919 - phosphoinositide-3-kinase regulatory subunit 4

Symbol

Pik3r4
Name

phosphoinositide-3-kinase regulatory subunit 4
Synonyms

p150, Vps15

Feature Type

protein coding gene
IDs

MGI:1922919
NCBI Gene: 75669
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:105520177-105564856 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 56.79 cM, cytoband F1
Mapping Data

4 experiments

SNPs within 2kb

1553 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922919	protein coding gene	Chr9:105520156-105564856 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035216	protein coding gene	Chr9:107375865-107424739 (+)
A/J	MGP_AJ_G0035196	protein coding gene	Chr9:103511451-103560566 (+)
AKR/J	MGP_AKRJ_G0035128	protein coding gene	Chr9:106090257-106138155 (+)
BALB/cJ	MGP_BALBcJ_G0035189	protein coding gene	Chr9:103201506-103249414 (+)
C3H/HeJ	MGP_C3HHeJ_G0034899	protein coding gene	Chr9:106490023-106538883 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035709	protein coding gene	Chr9:110352035-110396744 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032607	protein coding gene	Chr9:101023002-101073120 (+)
CAST/EiJ	MGP_CASTEiJ_G0034211	protein coding gene	Chr9:106391390-106438301 (+)
CBA/J	MGP_CBAJ_G0034868	protein coding gene	Chr9:114189233-114247155 (+)
DBA/2J	MGP_DBA2J_G0035029	protein coding gene	Chr9:102982007-103030566 (+)
FVB/NJ	MGP_FVBNJ_G0034977	protein coding gene	Chr9:101751929-101801288 (+)
LP/J	MGP_LPJ_G0035105	protein coding gene	Chr9:107596138-107645521 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035016	protein coding gene	Chr9:115890550-115942037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035731	protein coding gene	Chr9:106340626-106389788 (+)
PWK/PhJ	MGP_PWKPhJ_G0033918	protein coding gene	Chr9:103277968-103323469 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033753	protein coding gene	Chr9:106391582-106439405 (+)
WSB/EiJ	MGP_WSBEiJ_G0034331	protein coding gene	Chr9:106219239-106276145 (+)

Human Ortholog

PIK3R4, phosphoinositide-3-kinase regulatory subunit 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIK3R4, phosphoinositide-3-kinase regulatory subunit 4
Synonyms

p150, VPS15
Links

HGNC:8982

NCBI Gene ID: 30849

UniProt: Q99570
Chr Location

3q22.1; chr3:130678934-130746829 (-) GRCh38

MGI Vertebrate Homology

Pik3r4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIK3R4
Gene Tree

Pik3r4

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Phenotype Summary

22 phenotypes from 3 alleles in 7 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit early embryonic lethality before E7.5. Mice homozygous for a conditional allele activated in muscles exhibit symptoms of autophagic vacuolar myopathies.

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All GO Annotations

72
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

7
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pik3r4

ZFIN pik3r4

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All Sequences

67
RefSeq

5
UniProt

6
CCDS

CCDS40753.1

Ensembl

ENSMUSG00000032571 (Evidence)
NCBI Gene

75669

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032571	Ensembl Gene Model \| MGI Sequence Detail	44680	C57BL/6J	± kb
transcript	ENSMUST00000191268	Ensembl \| MGI Sequence Detail	4756	Not Applicable
polypeptide	ENSMUSP00000139427	Ensembl \| MGI Sequence Detail	1358	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012727 phosphoinositide 3-kinase regulatory subunit 4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR021133 HEAT, type 2

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR045162 Serine/threonine-protein kinase Vps15-like

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q8VD65 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 3

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MGI:1196267, MGI:2143428, MGI:2442102

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 16

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:338761 Alkhoury C, et al., Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis. Nat Cell Biol. 2023 Jul;25(7):975-988

TSS for Pik3r4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86844	Chr9:105520156-105520235 (+)	19 bp
Tssr86845	Chr9:105535585-105535590 (+)	15,411 bp
Tssr86846	Chr9:105535601-105535625 (+)	15,436 bp
Tssr86847	Chr9:105535634-105535655 (+)	15,468 bp
Tssr86848	Chr9:105535678-105535688 (+)	15,506 bp
Tssr86849	Chr9:105535697-105535704 (+)	15,524 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24