Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PHLDB2
  • Mouse genes Phldb2
  • Rat genes Phldb2
  • Zfish genes phldb2a,phldb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Phldb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PHLDB2	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	PHLDB2	IPI	UniProtKB:P21333	Human	PMID:20236936
Molecular Function	GO:0005515	protein binding	PHLDB2	IPI	UniProtKB:P21333	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	Phldb2	IPI	UniProtKB:Q3U5C7	Mouse	PMID:27378169
Cellular Component	GO:0045180	basal cortex	PHLDB2	IDA		Human	PMID:23940118
Cellular Component	GO:0031252	cell leading edge	PHLDB2	IDA		Human	PMID:24859005
Cellular Component	GO:0005829	cytosol	PHLDB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	PHLDB2	IDA		Human	PMID:24859005
Cellular Component	GO:0045111	intermediate filament cytoskeleton	PHLDB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PHLDB2	IDA		Human	GO_REF:0000052
Biological Process	GO:0016477	cell migration	Phldb2	IGI	MGI:MGI:1916034	Mouse	PMID:27378169
Biological Process	GO:0030010	establishment of cell polarity	Phldb2	IGI	MGI:MGI:1916034	Mouse	PMID:27378169
Biological Process	GO:0045184	establishment of protein localization	PHLDB2	IMP		Human	PMID:24859005
Biological Process	GO:0000226	microtubule cytoskeleton organization	PHLDB2	IMP		Human	PMID:24859005
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	PHLDB2	IMP		Human	PMID:24859005
Biological Process	GO:0051497	negative regulation of stress fiber assembly	PHLDB2	IMP		Human	PMID:24859005
Biological Process	GO:1903690	negative regulation of wound healing, spreading of epidermal cells	PHLDB2	IMP		Human	PMID:24859005
Biological Process	GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	PHLDB2	IGI	UniProtKB:Q7Z460|UniProtKB:Q86UU1	Human	PMID:23940118
Biological Process	GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	PHLDB2	IGI	UniProtKB:Q86UU1	Human	PMID:23940118
Biological Process	GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	PHLDB2	IMP		Human	PMID:23940118
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	PHLDB2	IMP		Human	PMID:23940118
Biological Process	GO:0010470	regulation of gastrulation	PHLDB2	IMP		Human	PMID:23940118
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	PHLDB2	IGI	UniProtKB:Q7Z460|UniProtKB:Q86UU1	Human	PMID:23940118

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern