Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pfkl

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PFKL
- Mouse genes Pfkl
- Rat genes Pfkl
- Zfish genes pfkla,pfklb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pfkl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKL	IMP		Human	PMID:6227635
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKL	IDA		Human	PMID:22923583
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKL	IDA		Human	PMID:6444532
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKL	IDA		Human	PMID:6444721
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKL	IDA		Human	PMID:8780720
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Mouse	PMID:6450202
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Mouse	PMID:8172601
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Mouse	PMID:9287040
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:14342527\|RGD:2301230
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:156182\|RGD:2301234
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:1834654\|RGD:1599371
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:4273555\|RGD:2302790
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:6240262\|RGD:2301241
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:6446905\|RGD:2301237
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkl	IDA		Rat	PMID:6458283\|RGD:2301239
Molecular Function	GO:0005524	ATP binding	PFKL	IDA		Human	PMID:8780720
Molecular Function	GO:0005524	ATP binding	Pfkl	IDA		Rat	PMID:14342527\|RGD:2301230
Molecular Function	GO:0005524	ATP binding	Pfkl	IDA		Rat	PMID:156182\|RGD:2301234
Molecular Function	GO:0005524	ATP binding	Pfkl	IDA		Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0005524	ATP binding	Pfkl	IDA		Rat	PMID:6446905\|RGD:2301237
Molecular Function	GO:0005524	ATP binding	Pfkl	IDA		Rat	PMID:6458283\|RGD:2301239
Molecular Function	GO:0070061	fructose binding	PFKL	IDA		Human	PMID:8780720
Molecular Function	GO:0070095	fructose-6-phosphate binding	PFKL	IDA		Human	PMID:6444721
Molecular Function	GO:0070095	fructose-6-phosphate binding	Pfkl	IDA		Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0070095	fructose-6-phosphate binding	Pfkl	IDA		Rat	PMID:4273555\|RGD:2302790
Molecular Function	GO:0042802	identical protein binding	PFKL	IPI	UniProtKB:P17858	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	PFKL	IPI	UniProtKB:P17858	Human	PMID:6444721
Molecular Function	GO:0042802	identical protein binding	Pfkl	IPI	RGD:3311	Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0019900	kinase binding	PFKL	IPI	UniProtKB:P08237	Human	PMID:6444721
Molecular Function	GO:0048029	monosaccharide binding	Pfkl	IDA		Rat	PMID:14342527\|RGD:2301230
Molecular Function	GO:0048029	monosaccharide binding	Pfkl	IDA		Rat	PMID:156182\|RGD:2301234
Molecular Function	GO:0048029	monosaccharide binding	Pfkl	IDA		Rat	PMID:6446905\|RGD:2301237
Molecular Function	GO:0048029	monosaccharide binding	Pfkl	IDA		Rat	PMID:6458283\|RGD:2301239
Molecular Function	GO:0005515	protein binding	PFKL	IPI	UniProtKB:P08237	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	PFKL	IPI	UniProtKB:O15294	Human	PMID:22923583
Molecular Function	GO:0005515	protein binding	PFKL	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PFKL	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PFKL	IPI	UniProtKB:Q969Y2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PFKL	IPI	UniProtKB:P08237	Human	PMID:6444721
Cellular Component	GO:0005945	6-phosphofructokinase complex	PFKL	IDA		Human	PMID:6444532
Cellular Component	GO:0005945	6-phosphofructokinase complex	PFKL	IDA		Human	PMID:6444721
Cellular Component	GO:0005829	cytosol	PFKL	HDA		Human	PMID:16780588
Cellular Component	GO:0005829	cytosol	Pfkl	IDA		Mouse	PMID:2521854
Cellular Component	GO:0005829	cytosol	Pfkl	IDA		Rat	PMID:1834654\|RGD:1599371
Cellular Component	GO:0005829	cytosol	Pfkl	IDA		Rat	PMID:6240262\|RGD:2301241
Cellular Component	GO:0070062	extracellular exosome	PFKL	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PFKL	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	PFKL	HDA		Human	PMID:20458337
Cellular Component	GO:0016020	membrane	PFKL	HDA		Human	PMID:19946888
Biological Process	GO:0005975	carbohydrate metabolic process	Pfkl	IDA		Rat	PMID:1834654\|RGD:1599371
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	PFKL	IDA		Human	PMID:22923583
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	Pfkl	IDA		Rat	PMID:2931076\|RGD:2302736
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	Pfkl	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	PFKL	IMP		Human	PMID:6227635
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	PFKL	IDA		Human	PMID:6444532
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	PFKL	IDA		Human	PMID:6444721
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Mouse	PMID:8172601
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Mouse	PMID:9287040
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Rat	PMID:14342527\|RGD:2301230
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Rat	PMID:156182\|RGD:2301234
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Rat	PMID:2931076\|RGD:2302736
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Rat	PMID:6240262\|RGD:2301241
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Rat	PMID:6446905\|RGD:2301237
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkl	IDA		Rat	PMID:6458283\|RGD:2301239
Biological Process	GO:0006096	glycolytic process	PFKL	IDA		Human	PMID:22923583
Biological Process	GO:0006096	glycolytic process	PFKL	IDA		Human	PMID:6227635
Biological Process	GO:0006096	glycolytic process	PFKL	IDA		Human	PMID:6444532
Biological Process	GO:0006096	glycolytic process	Pfkl	IDA		Rat	PMID:2931076\|RGD:2302736
Biological Process	GO:0006096	glycolytic process	Pfkl	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0006096	glycolytic process	Pfkl	IDA		Rat	PMID:4353083\|RGD:2302851
Biological Process	GO:0006096	glycolytic process	Pfkl	IDA		Rat	PMID:6458283\|RGD:2301239
Biological Process	GO:0061615	glycolytic process through fructose-6-phosphate	Pfkl	IDA		Mouse	PMID:8172601
Biological Process	GO:0061615	glycolytic process through fructose-6-phosphate	Pfkl	IMP		Mouse	PMID:35530161
Biological Process	GO:0061615	glycolytic process through fructose-6-phosphate	Pfkl	IDA		Mouse	PMID:9287040
Biological Process	GO:0046676	negative regulation of insulin secretion	Pfkl	IDA		Mouse	PMID:9287040
Biological Process	GO:0009749	response to glucose	PFKL	IDA		Human	PMID:22923583
Biological Process	GO:0009749	response to glucose	Pfkl	IDA		Mouse	PMID:9287040

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.