Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDGFC
  • Mouse genes Pdgfc
  • Rat genes Pdgfc
  • Zfish genes pdgfc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdgfc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	PDGFC	IPI	UniProtKB:P16234	Human	PMID:10806482
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	Pdgfc	IDA		Mouse	PMID:15372073
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	Pdgfc	IDA		Mouse	PMID:10806482
Molecular Function	GO:0005515	protein binding	PDGFC	IPI	UniProtKB:P16234	Human	PMID:10806482
Molecular Function	GO:0005515	protein binding	PDGFC	IPI	UniProtKB:P16234	Human	PMID:35384245
Molecular Function	GO:0042803	protein homodimerization activity	PDGFC	IPI	UniProtKB:Q9NRA1	Human	PMID:10806482
Cellular Component	GO:0009986	cell surface	PDGFC	IDA		Human	PMID:10806482
Cellular Component	GO:0005829	cytosol	PDGFC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	PDGFC	HDA		Human	PMID:19199708
Cellular Component	GO:0005576	extracellular region	Pdgfc	IDA		Mouse	PMID:10806482
Cellular Component	GO:0005615	extracellular space	PDGFC	IDA		Human	PMID:10806482
Cellular Component	GO:0005886	plasma membrane	PDGFC	IDA		Human	GO_REF:0000052
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	Pdgfc	IDA		Mouse	PMID:10806482
Biological Process	GO:0009887	animal organ morphogenesis	Pdgfc	IGI	MGI:MGI:97527	Mouse	PMID:15361870
Biological Process	GO:0009887	animal organ morphogenesis	Pdgfc	IMP	MGI:MGI:3510799	Mouse	PMID:15361870
Biological Process	GO:0060348	bone development	Pdgfc	IGI	MGI:MGI:97527	Mouse	PMID:23938297
Biological Process	GO:0071230	cellular response to amino acid stimulus	Pdgfc	IDA		Mouse	PMID:20548288
Biological Process	GO:0048565	digestive tract development	Pdgfc	IGI	MGI:MGI:97527	Mouse	PMID:23938297
Biological Process	GO:0048144	fibroblast proliferation	Pdgfc	IDA		Mouse	PMID:15234987
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	PDGFC	IDA		Human	PMID:10806482
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Pdgfc	IDA		Mouse	PMID:15372073
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFC	IDA		Human	PMID:10806482
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pdgfc	IDA		Mouse	PMID:10806482
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Pdgfc	IMP		Mouse	MGI:MGI:5883162|PMID:27492130
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	PDGFC	IDA		Human	PMID:10806482
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Pdgfc	IDA		Mouse	PMID:15234987
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Pdgfc	IDA		Mouse	PMID:11940581

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern