Pdgfc
Gene Detail

Symbol Name ID

Pdgfc platelet-derived growth factor, C polypeptide MGI:1859631

Synonyms

1110064L01Rik, PDGF-C

Feature Type

protein coding gene

Genetic Map

Chromosome 3

35.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:81036416-81214040 bp, + strand From VEGA annotation of GRCm38   177625 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pdgfc ± 2 cM)

Protein SuperFamily: platelet- derived growth factor, PDGF C/PDGF D types
Gene Tree: Pdgfc

Human ortholog

PDGFC platelet derived growth factor C NCBI Gene ID 56034
Human Synonyms: FALLOTEIN, SCDGF
Human Chr4:157682764-157892546 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(24) : Targeted(7) Gene trapped(17)
 

Homozygous mutation of this gene results neonatal and postnatal lethality with cleft palate, hypoplastic palatine bones, edema, blistering, and a short nasal septum with one allele or abnormal retinal pigmentation with a second allele.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	activation of transmembrane receptor protein tyrosine kinase activity, cellular response to amino acid stimulus, ...
Component	cytoplasm, extracellular region, ...
Function	cell surface binding, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (410)    Tissues (131)    Images (54)
Theiler Stages: 2, 3, 15, 19, 20, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	72
RNA in situ	293
Northern blot	8
Western blot	1
RT-PCR	36

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028878 (Evidence)
Ensembl Gene Model	ENSMUSG00000028019 (Evidence)
Entrez Gene	54635 (Evidence)
DFCI	TC1576974, TC1632484, TC1654717, TC1682946
DoTS	DT.101373630, DT.50316584, DT.91443270, DT.94264226
NIA Mouse Gene Index	U003355
Consensus CDS Project	CCDS17425.1
International Mouse Knockout Project Status	Pdgfc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028878	VEGA Gene Model | MGI Sequence Detail	177625	C57BL/6J
transcript	OTTMUST00000071532	VEGA | MGI Sequence Detail	3521	Not Applicable
polypeptide	OTTMUSP00000036670	VEGA | MGI Sequence Detail	345	Not Applicable

All sequences(44) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(1186 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000859	CUB
InterPro	IPR000072	Platelet-derived growth factor (PDGF)
Protein Ontology	PR:000000703	platelet-derived growth factor C

References

(Earliest) J:62052 Li X, et al., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
(Latest) J:192236 Martin IV, et al., Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis. Am J Pathol. 2013 Jan;182(1):107-17
All references(68)

Other accession IDs

MGI:1916128, MGI:2139772