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Pdgfc
Gene Detail
Symbol

Name
ID
Pdgfc
platelet-derived growth factor, C polypeptide
MGI:1859631
Synonyms
1110064L01Rik, PDGF-C
Feature Type
protein coding gene
Genetic Map
Chromosome 3
35.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:81036416-81214040 bp, + strand
From VEGA annotation of GRCm38

  177625 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9423  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDGFC
Protein SuperFamily: platelet- derived growth factor, PDGF C/PDGF D types
Gene Tree: Pdgfc

Human
homologs
PDGFC, platelet derived growth factor C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56034
neXtProt AC: NX_Q9NRA1

Human Synonyms: FALLOTEIN, SCDGF

Human Chr (Location): 4q32; chr4:156761611-156971394 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(17) Targeted(7) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results neonatal and postnatal lethality with cleft palate, hypoplastic palatine bones, edema, blistering, and a short nasal septum with one allele or abnormal retinal pigmentation with a second allele.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Pdgfc interacts with 330 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (23 records)
Data Summary: Results (418)    Tissues (132)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 72
RNA in situ 301
Northern blot 8
Western blot 1
RT-PCR 36
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PDGFC ; Xenbase pdgfc    NEW 
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028878 (Evidence)
Ensembl Gene Model ENSMUSG00000028019 (Evidence)
Entrez Gene 54635 (Evidence)
DFCI TC1654717, TC1632484, TC1576974, TC1682946
DoTS DT.101373630, DT.91443270, DT.94264226, DT.50316584
NIA Mouse Gene Index U003355
Consensus CDS Project CCDS17425.1
International Mouse Phenotyping Consortium Status Pdgfc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028878 VEGA Gene Model | MGI Sequence Detail 177625 C57BL/6J ±  kb
transcript OTTMUST00000071532 VEGA | MGI Sequence Detail 3521 Not Applicable 
polypeptide OTTMUSP00000036670 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(1638 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1642)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000000703 platelet-derived growth factor C
References
(Earliest) J:62052 Li X, et al., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
(Latest) J:216447 He C, et al., Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14806-11
All references(73)
Other
accession IDs
MGI:1916128, MGI:2139772

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory