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Pdgfc Gene Detail
Summary
  • Symbol
    Pdgfc
  • Name
    platelet-derived growth factor, C polypeptide
  • Synonyms
    1110064L01Rik, PDGF-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859631
    NCBI Gene: 54635
  • Gene Overview
    MyGene.info: PDGFC
Location & Maps
more
  • Sequence Map
    Chr3:81036416-81214040 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      177625 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 35.73 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PDGFC, platelet derived growth factor C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDGFC, platelet derived growth factor C
    Orthology source: HomoloGene
  • Synonyms
    FALLOTEIN, SCDGF
  • Links
    NCBI Gene ID: 56034
    neXtProt AC: NX_Q9NRA1

  • Chr Location
    4q32; chr4:156761611-156971394 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 5 genetic backgrounds
    45 phenotypes from multigenic genotypes
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    2 involving Pdgfc
  • Incidental Mutations
    APF
Homozygous mutation of this gene results neonatal and postnatal lethality with cleft palate, hypoplastic palatine bones, edema, blistering, and a short nasal septum with one allele or abnormal retinal pigmentation with a second allele.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028878 VEGA Gene Model | MGI Sequence Detail 177625 C57BL/6J ±  kb
transcript OTTMUST00000071532 VEGA | MGI Sequence Detail 3521 Not Applicable  
polypeptide OTTMUSP00000036670 VEGA | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1628 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916128, MGI:2139772
References
more
  • Summaries
    All 73
    Developmental Gene Expression 24
    Diseases 2
    Gene Ontology 11
    Phenotypes 25
  • Earliest
    J:62052 Li X, et al., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
  • Latest
    J:232500 Andrae J, et al., A role for PDGF-C/PDGFRalpha signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex. Biol Open. 2016;5(4):461-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory