Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pde4d

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PDE4D
- Mouse genes Pde4d
- Rat genes Pde4d
- Zfish genes pde4d
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde4d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE4D	IDA		Human	PMID:17404263
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE4D	IGI	UniProtKB:P06776\|UniProtKB:P22434	Human	PMID:8413254
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE4D	IDA		Human	PMID:9371713
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde4d	IDA		Mouse	MGI:MGI:5286798\|PMID:21670503
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Pde4d	IDA		Mouse	PMID:10518565
Molecular Function	GO:0051117	ATPase binding	PDE4D	IPI	UniProtKB:P16615	Human	PMID:21903937
Molecular Function	GO:0051117	ATPase binding	Pde4d	IPI	UniProtKB:O55143	Mouse	MGI:MGI:5442270\|PMID:21903937
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	Pde4d	IPI	UniProtKB:P18762	Rat	PMID:19801680\|RGD:7327160
Molecular Function	GO:0030552	cAMP binding	PDE4D	IDA		Human	PMID:15938621
Molecular Function	GO:0030552	cAMP binding	PDE4D	IDA		Human	PMID:9371713
Molecular Function	GO:0004112	cyclic-nucleotide phosphodiesterase activity	Pde4d	IDA		Rat	PMID:12834813\|RGD:633641
Molecular Function	GO:0019899	enzyme binding	Pde4d	IPI	RGD:631375	Rat	PMID:22975349\|RGD:8554232
Molecular Function	GO:0019899	enzyme binding	Pde4d	IPI	UniProtKB:P59722	Rat	PMID:22975349\|RGD:8554232
Molecular Function	GO:1901363	heterocyclic compound binding	PDE4D	IPI	CHEBI:104872	Human	PMID:9371713
Molecular Function	GO:0005515	protein binding	PDE4D	IPI	UniProtKB:P32121	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	PDE4D	IPI	UniProtKB:P32121	Human	PMID:19955404
Molecular Function	GO:0005515	protein binding	PDE4D	IPI	UniProtKB:P38432	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE4D	IPI	UniProtKB:P43360	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE4D	IPI	UniProtKB:Q08AF8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE4D	IPI	UniProtKB:Q0D2H9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE4D	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	UniProtKB:P34971	Mouse	MGI:MGI:3773471\|PMID:18188154
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	UniProtKB:Q99996	Mouse	PMID:19218243
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	UniProtKB:B1AWC9	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	PR:Q9CZA6	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	RGD:708410	Rat	PMID:11134006\|RGD:1299425
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	RGD:620833	Rat	PMID:11285255\|RGD:9685532
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	UniProtKB:Q9QX74	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Pde4d	IPI	UniProtKB:P08588	Rat	PMID:23381222\|RGD:8554358
Molecular Function	GO:0097110	scaffold protein binding	PDE4D	IPI	UniProtKB:Q9WVC7	Human	PMID:15182229
Molecular Function	GO:0044325	transmembrane transporter binding	PDE4D	IPI	UniProtKB:Q92736	Human	PMID:16213210
Molecular Function	GO:0044325	transmembrane transporter binding	Pde4d	IPI	UniProtKB:E9Q401	Mouse	MGI:MGI:3690823\|PMID:16213210
Molecular Function	GO:0044325	transmembrane transporter binding	Pde4d	IPI	UniProtKB:Q01815	Mouse	MGI:MGI:5286798\|PMID:21670503
Cellular Component	GO:0034704	calcium channel complex	PDE4D	IDA		Human	PMID:16213210
Cellular Component	GO:0034704	calcium channel complex	Pde4d	IDA		Mouse	MGI:MGI:3690823\|PMID:16213210
Cellular Component	GO:0005813	centrosome	Pde4d	IDA		Mouse	PMID:18983980
Cellular Component	GO:0005813	centrosome	Pde4d	IDA		Rat	PMID:11134006\|RGD:1299425
Cellular Component	GO:0005829	cytosol	PDE4D	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pde4d	IDA		Rat	PMID:18073242\|RGD:2312596
Cellular Component	GO:0005794	Golgi apparatus	Pde4d	IDA		Rat	PMID:11134006\|RGD:1299425
Cellular Component	GO:0030016	myofibril	Pde4d	IDA		Rat	PMID:11134006\|RGD:1299425
Cellular Component	GO:0005886	plasma membrane	PDE4D	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Pde4d	IDA		Rat	PMID:18073242\|RGD:2312596
Cellular Component	GO:0034705	potassium channel complex	Pde4d	IDA		Mouse	PMID:19218243
Cellular Component	GO:0034705	potassium channel complex	Pde4d	IPI	UniProtKB:Q99996	Mouse	PMID:19218243
Cellular Component	GO:0032991	protein-containing complex	Pde4d	IDA		Rat	PMID:11296225\|RGD:68716
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Pde4d	IDA		Mouse	MGI:MGI:5286798\|PMID:21670503
Biological Process	GO:0071875	adrenergic receptor signaling pathway	Pde4d	IMP		Rat	PMID:19801680\|RGD:7327160
Biological Process	GO:0019933	cAMP-mediated signaling	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:10518565
Biological Process	GO:0019933	cAMP-mediated signaling	Pde4d	IDA		Mouse	PMID:10518565
Biological Process	GO:0071320	cellular response to cAMP	Pde4d	IDA		Mouse	PMID:19218243
Biological Process	GO:0071872	cellular response to epinephrine stimulus	Pde4d	IMP		Mouse	MGI:MGI:3690823\|PMID:16213210
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Pde4d	IMP	MGI:MGI:2451182	Mouse	PMID:10518565
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:10518565
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:15585880
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Pde4d	IMP	MGI:MGI:3525068	Mouse	PMID:15585880
Biological Process	GO:0061028	establishment of endothelial barrier	Pde4d	IDA		Rat	PMID:20139324\|RGD:8553884
Biological Process	GO:0030324	lung development	Pde4d	IEP		Rat	PMID:20652950\|RGD:7327159
Biological Process	GO:0007613	memory	Pde4d	IEP		Rat	PMID:15302115\|RGD:1582523
Biological Process	GO:0007613	memory	Pde4d	IMP		Rat	PMID:21649644\|RGD:7327158
Biological Process	GO:0035264	multicellular organism growth	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:10518565
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	PDE4D	IMP		Human	PMID:19252089
Biological Process	GO:0045822	negative regulation of heart contraction	Pde4d	IMP		Mouse	MGI:MGI:5442270\|PMID:21903937
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Pde4d	IMP		Mouse	MGI:MGI:3690823\|PMID:16213210
Biological Process	GO:1901898	negative regulation of relaxation of cardiac muscle	Pde4d	IMP		Mouse	MGI:MGI:5286798\|PMID:21670503
Biological Process	GO:0030593	neutrophil chemotaxis	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:15585880
Biological Process	GO:1990266	neutrophil migration	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:15585880
Biological Process	GO:0001542	ovulation from ovarian follicle	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:10518565
Biological Process	GO:0001542	ovulation from ovarian follicle	Pde4d	IMP	MGI:MGI:2451182	Mouse	PMID:10518565
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Pde4d	IMP		Rat	PMID:18073242\|RGD:2312596
Biological Process	GO:0032743	positive regulation of interleukin-2 production	PDE4D	IMP		Human	PMID:17404263
Biological Process	GO:0032754	positive regulation of interleukin-5 production	PDE4D	IMP		Human	PMID:17404263
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Pde4d	IDA		Rat	PMID:18073242\|RGD:2312596
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Pde4d	IMP		Rat	PMID:21776361\|RGD:7327157
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Pde4d	IMP		Rat	PMID:21776361\|RGD:7327157
Biological Process	GO:0032729	positive regulation of type II interferon production	PDE4D	IMP		Human	PMID:17404263
Biological Process	GO:0065003	protein-containing complex assembly	Pde4d	IDA		Rat	PMID:11134006\|RGD:1299425
Biological Process	GO:0043949	regulation of cAMP-mediated signaling	Pde4d	IMP		Rat	PMID:18073242\|RGD:2312596
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Pde4d	IMP		Mouse	MGI:MGI:5286798\|PMID:21670503
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Pde4d	IMP		Mouse	MGI:MGI:5442270\|PMID:21903937
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Pde4d	IMP		Rat	PMID:19801680\|RGD:7327160
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	Pde4d	IDA		Rat	PMID:12552097\|RGD:629543
Biological Process	GO:0002027	regulation of heart rate	Pde4d	IMP		Mouse	MGI:MGI:3690823\|PMID:16213210
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Pde4d	IMP		Mouse	MGI:MGI:3690823\|PMID:16213210
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Pde4d	IMP		Mouse	MGI:MGI:3690823\|PMID:16213210
Biological Process	GO:0010469	regulation of signaling receptor activity	Pde4d	IMP		Rat	PMID:19801680\|RGD:7327160
Biological Process	GO:0006939	smooth muscle contraction	Pde4d	IMP	MGI:MGI:2451168	Mouse	PMID:14519662
Biological Process	GO:0050852	T cell receptor signaling pathway	PDE4D	IMP		Human	PMID:17404263

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.