Pde4d
Gene Detail

Symbol Name ID

Pde4d phosphodiesterase 4D, cAMP specific MGI:99555

Synonyms

9630011N22Rik, Dpde3, dunce

Feature Type

protein coding gene

Genetic Map

Chromosome 13

59.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr13:108449948-109953461 bp, + strand From VEGA annotation of GRCm38   1503514 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pde4d ± 2 cM)

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent

Human ortholog

PDE4D phosphodiesterase 4D, cAMP-specific NCBI Gene ID 5144
Human Synonyms: ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
Human Chr5:58264865-59783925 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PDE4D (2)

Alleles and phenotypes

All alleles(131) : Targeted(4) Gene trapped(127)
 

Homozygotes for targeted null mutations exhibit delayed growth, female infertility associated with impaired ovulation, and reduced postnatal viability.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	aging, cAMP catabolic process, ...
Component	centrosome, cytoplasm, ...
Function	3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (93)    Tissues (93)    Images (18)
Theiler Stages: 22

Assay Type	Results
RNA in situ	93

cDNA source data(15)
External Resources: Allen Institute   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000031955 (Evidence)
Ensembl Gene Model	ENSMUSG00000074661 (Evidence), ENSMUSG00000021699 (Evidence)
Entrez Gene	238871, 100862401
DFCI	TC1585860, TC1599241, TC1616780, TC1619135, TC1636022, TC1652108, TC1667795, TC1717164
NIA Mouse Gene Index	U015238, U164410, U202996
EC	3.1.4.17
Consensus CDS Project	CCDS49359.1
International Mouse Knockout Project Status	Pde4d

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031955	VEGA Gene Model | MGI Sequence Detail	1503514	C57BL/6J
transcript	OTTMUST00000080693	VEGA | MGI Sequence Detail	2455	Not Applicable
polypeptide	OTTMUSP00000043004	VEGA | MGI Sequence Detail	803	Not Applicable

All sequences(110) UniProt(13)

Polymorphisms

RFLP(1) : SNPs(7500 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
InterPro	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro	IPR003607	HD/PDEase domain
Protein Ontology	PR:000012475	cAMP-specific 3',5'-cyclic phosphodiesterase 4D

References

(Earliest) J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
(Latest) J:184660 Kvajo M, et al., Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. Neuroscience. 2012 Jun 1;211:136-64
All references(64)

Other accession IDs

MGD-MRK-16333, MGI:2145249, MGI:2444663