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Pde4d Gene Detail
Summary
  • Symbol
    Pde4d
  • Name
    phosphodiesterase 4D, cAMP specific
  • Synonyms
    9630011N22Rik, Dpde3, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99555
    NCBI Gene: 238871
  • Gene Overview
    MyGene.info: PDE4D
  • Alliance
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:108654177-109955969 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 59.69 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8900 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99555
protein coding gene Chr13:108449948-109955969 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020927
protein coding gene Chr13:110761069-112335382 (+)
A/J MGP_AJ_G0020876
protein coding gene Chr13:106401791-107898773 (+)
AKR/J MGP_AKRJ_G0020852
protein coding gene Chr13:109614648-111158354 (+)
BALB/cJ MGP_BALBcJ_G0020877
protein coding gene Chr13:107126548-108607285 (+)
C3H/HeJ MGP_C3HHeJ_G0020666
protein coding gene Chr13:109402103-110932307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021312
protein coding gene Chr13:114091893-115714083 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018881
protein coding gene Chr13:101862598-103291495 (+)
CAST/EiJ MGP_CASTEiJ_G0020185
protein coding gene Chr13:108937880-110504012 (+)
CBA/J MGP_CBAJ_G0020628
protein coding gene Chr13:118487777-120157278 (+)
DBA/2J MGP_DBA2J_G0020751
protein coding gene Chr13:106159017-107627819 (+)
FVB/NJ MGP_FVBNJ_G0020734
protein coding gene Chr13:104813608-106304335 (+)
LP/J MGP_LPJ_G0020826
protein coding gene Chr13:110833105-112423021 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020762
protein coding gene Chr13:118882705-120560221 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021350
protein coding gene Chr13:109086987-110609014 (+)
PWK/PhJ MGP_PWKPhJ_G0019938
protein coding gene Chr13:104850051-106338308 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019760
protein coding gene Chr13:105336062-106887682 (+)
WSB/EiJ MGP_WSBEiJ_G0020243
protein coding gene Chr13:109635518-111181908 (+)



Homology
more
  • Human Ortholog
    PDE4D, phosphodiesterase 4D
  • Human Ortholog
    PDE4D, phosphodiesterase 4D
    Orthology source: HGNC
  • Synonyms
    ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
  • Links
    NCBI Gene ID: 5144
    neXtProt AC: NX_Q08499
    UniProt: Q08499

  • Chr Location
    5q11.2-q12.1; chr5:58969038-60488098 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PDE4D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed growth, female infertility associated with impaired ovulation, and reduced postnatal viability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238871 NCBI Gene Model | MGI Sequence Detail 1301793 C57BL/6J ±  kb
    transcript NM_011056 RefSeq | MGI Sequence Detail 7049 C57BL/6  
    polypeptide Q01063 UniProt | EBI | MGI Sequence Detail 747 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000012475 cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    • EC
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 23
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16333, MGI:2145249, MGI:2444663
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 24
    • Earliest
      J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
    • Latest
      J:240677 Crabtree GW, et al., Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness. J Neurosci. 2017 Apr 12;37(15):4158-4180

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory