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Pde4d
Gene Detail
 Symbol
Name
ID
Pde4d
phosphodiesterase 4D, cAMP specific
MGI:99555
Synonyms 9630011N22Rik, Dpde3, dunce
Feature Type protein coding gene
Genetic Map
Chromosome 13
59.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:108449948-109953461 bp, + strand
From VEGA annotation of GRCm38

  1503514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Mutations,
alleles, and
phenotypes
All mutations/alleles(131) : Gene trapped(127) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit delayed growth, female infertility associated with impaired ovulation, and reduced postnatal viability.
 
Phenotype Images(2)
Interactions
Pde4d interacts with 456 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process aging, cAMP catabolic process, ...
Component calcium channel complex, cytoplasm, ...
Function 3',5'-cyclic-nucleotide phosphodiesterase activity, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (93)    Tissues (93)    Images (18)
Theiler Stages: 22
Assay TypeResults
RNA in situ 93
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000031955 (Evidence)
Ensembl Gene ModelENSMUSG00000074661 (Evidence), ENSMUSG00000021699 (Evidence)
Entrez Gene238871 (Evidence)
DFCITC1585860, TC1594887, TC1599241, TC1616780, TC1619135, TC1636022, TC1652108, TC1667795, TC1717164
NIA Mouse Gene IndexU015238, U164410, U202996
EC3.1.4.53
Consensus CDS ProjectCCDS49359.1
International Mouse Knockout Project StatusPde4d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031955 VEGA Gene Model | MGI Sequence Detail 1503514 C57BL/6J ±  kb
transcript OTTMUST00000080693 VEGA | MGI Sequence Detail 2455 Not Applicable 
polypeptide OTTMUSP00000043004 VEGA | MGI Sequence Detail 803 Not Applicable 

For the selected sequences
All sequences(142) RefSeq(16) UniProt(16)
Polymorphisms RFLP(1) : SNPs within 2kb(10690 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012475 cAMP-specific 3',5'-cyclic phosphodiesterase 4D
References (Earliest) J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
(Latest) J:200285 Tian G, et al., Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion. J Cell Sci. 2012 Nov 1;125(Pt 21):5084-95
All references(62)
Other
accession IDs
MGD-MRK-16333, MGI:2145249, MGI:2444663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory