Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes P2RY6
  • Mouse genes P2ry6
  • Rat genes P2ry6
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2ry6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	P2RY6	IDA		Human	PMID:8670200
Molecular Function	GO:0045029	G protein-coupled UDP receptor activity	P2RY6	IDA		Human	PMID:8670200
Molecular Function	GO:0045029	G protein-coupled UDP receptor activity	P2ry6	IDA		Mouse	PMID:11259526
Molecular Function	GO:0045030	G protein-coupled UTP receptor activity	P2RY6	IDA		Human	PMID:8670200
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:O15162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P55060	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:Q14974	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P60328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:Q8NI22	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:Q9BYQ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:Q9BYR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:Q9BYR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P2RY6	IPI	UniProtKB:P28799	Human	PMID:32814053
Cellular Component	GO:0016324	apical plasma membrane	P2ry6	IDA		Rat	PMID:11557527|RGD:628452
Cellular Component	GO:0016323	basolateral plasma membrane	P2ry6	IDA		Rat	PMID:11557527|RGD:628452
Biological Process	GO:0071407	cellular response to organic cyclic compound	P2ry6	IDA		Mouse	PMID:23479225
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	P2ry6	IDA		Mouse	PMID:23479225
Biological Process	GO:0071415	cellular response to purine-containing compound	P2RY6	IDA		Human	PMID:8670200
Biological Process	GO:1905835	cellular response to pyrimidine ribonucleotide	P2RY6	IDA		Human	PMID:8670200
Biological Process	GO:1905835	cellular response to pyrimidine ribonucleotide	P2ry6	IMP		Rat	PMID:17410128|RGD:13673830
Biological Process	GO:0006909	phagocytosis	P2ry6	IMP		Rat	PMID:17410128|RGD:13673830
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	P2RY6	IDA		Human	PMID:28277742
Biological Process	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	P2ry6	IMP		Rat	PMID:17410128|RGD:13673830
Biological Process	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	P2RY6	IDA		Human	PMID:8670200
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	P2ry6	IMP		Rat	PMID:11934835|RGD:727358
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	P2RY6	IMP		Human	PMID:28277742
Biological Process	GO:0030321	transepithelial chloride transport	P2ry6	IDA		Mouse	PMID:11259526

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern