Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NRXN3
  • Mouse genes Nrxn3
  • Rat genes Nrxn3
  • Zfish genes nrxn3a,nrxn3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrxn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	Nrxn3	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Molecular Function	GO:0005246	calcium channel regulator activity	Nrxn3	IGI	MGI:MGI:1096362	Mouse	PMID:12827191
Molecular Function	GO:0005515	protein binding	Nrxn3	IPI	UniProtKB:O14522	Mouse	MGI:MGI:5508578|PMID:19816407
Molecular Function	GO:0005515	protein binding	Nrxn3	IPI	UniProtKB:Q8BGU2|UniProtKB:Q8BME9|UniProtKB:Q9R171	Mouse	MGI:MGI:6271505|PMID:29782851
Cellular Component	GO:0098982	GABA-ergic synapse	Nrxn3	IMP		Mouse	PMID:26030848
Cellular Component	GO:0098982	GABA-ergic synapse	Nrxn3	IDA		Mouse	PMID:26030848
Cellular Component	GO:0098978	glutamatergic synapse	Nrxn3	IDA		Mouse	PMID:27133466
Cellular Component	GO:0098978	glutamatergic synapse	Nrxn3	IMP		Mouse	PMID:27133466
Cellular Component	GO:0098978	glutamatergic synapse	Nrxn3	IDA		Mouse	PMID:26030848
Cellular Component	GO:0098978	glutamatergic synapse	Nrxn3	IMP		Mouse	PMID:26030848
Cellular Component	GO:0098793	presynapse	Nrxn3	IDA		Mouse	MGI:MGI:5662329|PMID:26030848
Cellular Component	GO:0032991	protein-containing complex	Nrxn3	IPI	PR:Q99JH7	Mouse	PMID:24613359
Cellular Component	GO:0032991	protein-containing complex	Nrxn3	IPI	UniProtKB:Q8N2Q7	Mouse	PMID:24613359
Biological Process	GO:0030534	adult behavior	NRXN3	IGI	UniProtKB:Q9HDB5	Human	PMID:22209245
Biological Process	GO:0007268	chemical synaptic transmission	Nrxn3	IGI	MGI:MGI:1096362	Mouse	PMID:12827191
Biological Process	GO:0007268	chemical synaptic transmission	Nrxn3	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Biological Process	GO:0007612	learning	NRXN3	IGI	UniProtKB:Q9HDB5	Human	PMID:22209245
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	Nrxn3	IDA		Mouse	PMID:27133466
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	Nrxn3	IMP		Mouse	PMID:27133466
Biological Process	GO:0007269	neurotransmitter secretion	Nrxn3	IGI	MGI:MGI:1096362	Mouse	PMID:12827191
Biological Process	GO:0007269	neurotransmitter secretion	Nrxn3	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Biological Process	GO:0097107	postsynaptic density assembly	Nrxn3	IMP		Mouse	PMID:27133466
Biological Process	GO:0097107	postsynaptic density assembly	Nrxn3	IDA		Mouse	PMID:27133466
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Nrxn3	IDA		Mouse	PMID:26030848
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Nrxn3	IMP		Mouse	PMID:26030848
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Nrxn3	IDA		Mouse	PMID:26030848
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Nrxn3	IMP		Mouse	PMID:26030848
Biological Process	GO:0035176	social behavior	NRXN3	IGI	UniProtKB:Q9HDB5	Human	PMID:22209245
Biological Process	GO:0007416	synapse assembly	Nrxn3	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Biological Process	GO:0007416	synapse assembly	Nrxn3	IGI	MGI:MGI:1096362	Mouse	PMID:12827191
Biological Process	GO:0099537	trans-synaptic signaling	Nrxn3	IDA		Mouse	PMID:26030848
Biological Process	GO:0099537	trans-synaptic signaling	Nrxn3	IMP		Mouse	PMID:26030848
Biological Process	GO:0071625	vocalization behavior	NRXN3	IGI	UniProtKB:Q9HDB5	Human	PMID:22209245

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern