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Nrxn3 Gene Detail
Summary
  • Symbol
    Nrxn3
  • Name
    neurexin III
  • Synonyms
    4933401A11Rik, 9330112C09Rik, D12Bwg0831e, neurexin III alpha, neurexin III alpha, neurexin III beta, neurexin III beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096389
    NCBI Gene: 18191
  • Gene Overview
    MyGene.info: NRXN3
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:88722876-90334935 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 42.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096389
protein coding gene Chr12:88722865-90334935 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019995
protein coding gene Chr12:89707381-91432015 (+)
A/J MGP_AJ_G0019950
protein coding gene Chr12:86364156-88014246 (+)
AKR/J MGP_AKRJ_G0019926
protein coding gene Chr12:88672121-90329941 (+)
BALB/cJ MGP_BALBcJ_G0019936
protein coding gene Chr12:86778465-88312072 (+)
C3H/HeJ MGP_C3HHeJ_G0019738
protein coding gene Chr12:89303656-90987656 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020385
protein coding gene Chr12:92394001-94130498 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017999
protein coding gene Chr12:83929560-85533959 (+)
CAST/EiJ MGP_CASTEiJ_G0019285
protein coding gene Chr12:84207160-85909147 (+)
CBA/J MGP_CBAJ_G0019710
protein coding gene Chr12:95895502-97703700 (+)
DBA/2J MGP_DBA2J_G0019821
protein coding gene Chr12:85854023-87477646 (+)
FVB/NJ MGP_FVBNJ_G0019810
protein coding gene Chr12:84746013-86372268 (+)
LP/J MGP_LPJ_G0019897
protein coding gene Chr12:89553338-91267955 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019851
protein coding gene Chr12:98577580-100376338 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020414
protein coding gene Chr12:88297009-89986431 (+)
PWK/PhJ MGP_PWKPhJ_G0019048
protein coding gene Chr12:80443152-82078594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018844
protein coding gene Chr12:82445208-84129168 (+)
WSB/EiJ MGP_WSBEiJ_G0019338
protein coding gene Chr12:89023505-90717700 (+)



Homology
more
  • Human Ortholog
    NRXN3, neurexin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NRXN3, neurexin 3
    Orthology source: HGNC
  • Synonyms
    C14orf60
  • Links
    NCBI Gene ID: 9369
    neXtProt AC: NX_Q9HDB5, NX_Q9Y4C0
    UniProt: Q9HDB5, Q9Y4C0

  • Chr Location
    14q24.3-q31.1; chr14:77979904-79868290 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Twenty percent of mice homozygous for a knock-out allele die postnatally prior to 20 days of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066392 Ensembl Gene Model | MGI Sequence Detail 1612060 C57BL/6J ±  kb
transcript ENSMUST00000163134 Ensembl | MGI Sequence Detail 7922 Not Applicable  
polypeptide ENSMUSP00000129678 Ensembl | MGI Sequence Detail 1571 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 18
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-34038, MGI:106346, MGI:1921683, MGI:1924757
References
more
  • Summaries
    All 57
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
  • Latest
    J:256883 Zhou J, et al., Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Biochim Biophys Acta. 2017 Dec;1860(12):1159-1168

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory