Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NRL
  • Mouse genes Nrl
  • Rat genes Nrl
  • Zfish genes nrl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NRL	IMP		Human	PMID:17335001
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NRL	IDA		Human	PMID:8552602
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nrl	IMP	MGI:MGI:2152376	Mouse	PMID:11694879
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nrl	IDA		Mouse	PMID:15689355
Molecular Function	GO:0043522	leucine zipper domain binding	NRL	IPI	UniProtKB:O43186	Human	PMID:10887186
Molecular Function	GO:1990841	promoter-specific chromatin binding	Nrl	IDA		Mouse	PMID:15163632
Molecular Function	GO:0005515	protein binding	NRL	IPI	UniProtKB:Q9XSK0	Human	PMID:10887186
Molecular Function	GO:0005515	protein binding	NRL	IPI	UniProtKB:Q9XSK0	Human	PMID:15028672
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NRL	IDA		Human	PMID:17335001
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NRL	IDA		Human	PMID:8552602
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NRL	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	NRL	IDA		Human	PMID:11477108
Cellular Component	GO:0005829	cytosol	NRL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NRL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NRL	IDA		Human	PMID:11477108
Cellular Component	GO:0005634	nucleus	NRL	IDA		Human	PMID:17335001
Biological Process	GO:0010628	positive regulation of gene expression	Nrl	IGI	MGI:MGI:1194883	Mouse	PMID:15689355
Biological Process	GO:0010628	positive regulation of gene expression	Nrl	IDA		Mouse	PMID:15689355
Biological Process	GO:0010628	positive regulation of gene expression	Nrl	IMP	MGI:MGI:2152376	Mouse	PMID:11694879
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NRL	IMP		Human	PMID:17335001
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NRL	IMP		Human	PMID:21981118
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NRL	IDA		Human	PMID:8552602
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nrl	IDA		Mouse	PMID:15689355
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nrl	IMP	MGI:MGI:2152376	Mouse	PMID:15163632
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nrl	IGI	MGI:MGI:1194883	Mouse	PMID:15689355
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nrl	IMP	MGI:MGI:2152376	Mouse	PMID:11694879
Biological Process	GO:0046549	retinal cone cell development	nrl	IMP	ZFIN:ZDB-GENO-221220-1	Zfish	PMID:35245286
Biological Process	GO:0046548	retinal rod cell development	Nrl	IMP	MGI:MGI:2152376	Mouse	PMID:11694879
Biological Process	GO:0046548	retinal rod cell development	nrl	IGI	ZFIN:ZDB-GENO-221220-3	Zfish	PMID:35245286
Biological Process	GO:0046548	retinal rod cell development	nrl	IMP	ZFIN:ZDB-GENO-221220-2	Zfish	PMID:35245286
Biological Process	GO:0046548	retinal rod cell development	nrl	IGI	ZFIN:ZDB-GENO-221220-4	Zfish	PMID:35245286
Biological Process	GO:0046548	retinal rod cell development	nrl	IMP	ZFIN:ZDB-GENO-221220-1	Zfish	PMID:35245286

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern