Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLRC3
  • Mouse genes Nlrc3
  • Rat genes Nlrc3
  • Zfish genes nlrc3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Nlrc3	IDA		Mouse	MGI:MGI:5883388|PMID:27951586
Molecular Function	GO:0005515	protein binding	NLRC3	IPI	UniProtKB:Q86WV6	Human	PMID:24560620
Molecular Function	GO:0005515	protein binding	NLRC3	IPI	UniProtKB:Q9UHD2	Human	PMID:24560620
Molecular Function	GO:0005515	protein binding	NLRC3	IPI	UniProtKB:Q9ULZ3	Human	PMID:25277106
Molecular Function	GO:0005515	protein binding	Nlrc3	IPI	PR:P70196	Mouse	PMID:22863753
Cellular Component	GO:0034451	centriolar satellite	NLRC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	NLRC3	IDA		Human	PMID:15705585
Cellular Component	GO:0005737	cytoplasm	NLRC3	IDA		Human	PMID:24560620
Cellular Component	GO:0005737	cytoplasm	NLRC3	IDA		Human	PMID:25277106
Cellular Component	GO:0005829	cytosol	NLRC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	NLRC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	NLRC3	IDA		Human	PMID:24560620
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	NLRC3	IDA		Human	PMID:15705585
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Nlrc3	IGI	MGI:MGI:108072	Mouse	PMID:22863753
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Nlrc3	IMP		Mouse	PMID:22863753
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Nlrc3	IMP		Mouse	MGI:MGI:5568884|PMID:24560620
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Nlrc3	IMP		Mouse	MGI:MGI:5883388|PMID:27951586
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Nlrc3	IMP		Mouse	MGI:MGI:5883388|PMID:27951586
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	NLRC3	IMP		Human	PMID:22863753
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Nlrc3	IGI	MGI:MGI:108072	Mouse	PMID:22863753
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Nlrc3	IMP		Mouse	PMID:22863753
Biological Process	GO:0050728	negative regulation of inflammatory response	NLRC3	IDA		Human	PMID:25277106
Biological Process	GO:0050728	negative regulation of inflammatory response	Nlrc3	IMP		Mouse	MGI:MGI:5568884|PMID:24560620
Biological Process	GO:0045824	negative regulation of innate immune response	Nlrc3	IMP		Mouse	MGI:MGI:5568884|PMID:24560620
Biological Process	GO:0032687	negative regulation of interferon-alpha production	Nlrc3	IMP		Mouse	MGI:MGI:5568884|PMID:24560620
Biological Process	GO:0032688	negative regulation of interferon-beta production	Nlrc3	IMP		Mouse	MGI:MGI:5568884|PMID:24560620
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Nlrc3	IMP		Mouse	MGI:MGI:5437524|PMID:22863753
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Nlrc3	IMP		Mouse	MGI:MGI:5437524|PMID:22863753
Biological Process	GO:0032715	negative regulation of interleukin-6 production	NLRC3	IDA		Human	PMID:22863753
Biological Process	GO:0032715	negative regulation of interleukin-6 production	NLRC3	IMP		Human	PMID:22863753
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Nlrc3	IMP		Mouse	MGI:MGI:5568884|PMID:24560620
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Nlrc3	IMP		Mouse	MGI:MGI:5437524|PMID:22863753
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	NLRC3	IDA		Human	PMID:15705585
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	NLRC3	IDA		Human	PMID:25277106
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	NLRC3	IDA		Human	PMID:25277106
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	Nlrc3	IMP		Mouse	MGI:MGI:5883388|PMID:27951586
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	NLRC3	IDA		Human	PMID:22863753
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	NLRC3	IMP		Human	PMID:22863753
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Nlrc3	IMP		Mouse	MGI:MGI:5437524|PMID:22863753
Biological Process	GO:0031396	regulation of protein ubiquitination	Nlrc3	IDA		Mouse	PMID:22863753
Biological Process	GO:0031396	regulation of protein ubiquitination	Nlrc3	IMP	MGI:MGI:5439971	Mouse	PMID:22863753
Biological Process	GO:0032496	response to lipopolysaccharide	Nlrc3	IMP	MGI:MGI:5439971	Mouse	PMID:22863753
Biological Process	GO:0042110	T cell activation	NLRC3	IEP		Human	PMID:15705585

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern