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Nlrc3 Gene Detail
Summary
  • Symbol
    Nlrc3
  • Name
    NLR family, CARD domain containing 3
  • Synonyms
    Caterpiller 16.2, CLR16.2, D230007K08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444070
    NCBI Gene: 268857
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:3762871-3794496 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    715 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444070
 protein coding gene Chr16:3762871-3796881 (-)
129S1/SvImJ ENSMUSG00200009905
 protein coding gene Chr16:754235-785860 (-)
A/J ENSMUSG00195010393
 protein coding gene Chr16:306623-338022 (-)
AKR/J ENSMUSG00220016944
 protein coding gene Chr16:605575-637196 (-)
BALB/cJ ENSMUSG00180007646
 protein coding gene Chr16:555145-586774 (-)
C3H/HeJ ENSMUSG00175027626
 protein coding gene Chr16:746463-778088 (-)
C57BL/6NJ ENSMUSG00215018933
 protein coding gene Chr16:427691-459320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020394
 protein coding gene Chr16:224811-252292 (-)
CAST/EiJ ENSTCUG00005029816
 protein coding gene Chr16:629429-661836 (-)
CBA/J ENSMUSG00210011685
 protein coding gene Chr16:763787-795412 (-)
DBA/2J ENSMUSG00185009147
 protein coding gene Chr16:708989-740614 (-)
FVB/NJ ENSMUSG00205009704
 protein coding gene Chr16:630366-661897 (-)
JF1/MsJ ENSUMUG00000032024
 protein coding gene Chr16:723114-755556 (-)
LP/J ENSMUSG00230010852
 protein coding gene Chr16:3250015-3281640 (-)
NOD/ShiLtJ ENSMUSG00190022129
 protein coding gene Chr16:784404-816027 (-)
NZO/HlLtJ ENSMUSG00225022746
 protein coding gene Chr16:6492366-6523989 (-)
PWK/PhJ ENSLUMG00010017484
 protein coding gene Chr16:601526-633935 (-)
SPRET/EiJ ENSMSPG00010017139
 protein coding gene Chr16:571070-601705 (-)
WSB/EiJ ENSIUOG00005015580
 protein coding gene Chr16:748740-780436 (-)



Homology
more
  • Human Ortholog
    NLRC3, NLR family CARD domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRC3, NLR family CARD domain containing 3
  • Synonyms
    CLR16.2, NOD3
  • Links
    NCBI Gene ID: 197358
    UniProt: Q7RTR2

  • Chr Location
    16p13.3; chr16:3539033-3577403 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced susceptibility to LPS-induced toxic shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049871 Ensembl Gene Model | MGI Sequence Detail 31626 C57BL/6J ±  kb
    transcript ENSMUST00000229884 Ensembl | MGI Sequence Detail 3600 Not Applicable  
    polypeptide ENSMUSP00000155241 Ensembl | MGI Sequence Detail 1199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:390544 Huang S, et al., NLRC3 suppresses hepatocarcinogenesis by disrupting the HSP90-mediated TRAF6/MYC signalling activation. Biochim Biophys Acta Mol Basis Dis. 2026 Aug 3;1872(8):168391
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory