Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLGN4X,NLGN4Y
  • Mouse genes Nlgn4l
  • Rat genes
  • Zfish genes nlgn4xb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlgn4l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031404	chloride ion binding	NLGN4X	IDA		Human	PMID:18093521
Molecular Function	GO:0042043	neurexin family protein binding	NLGN4X	IPI	UniProtKB:Q63373	Human	PMID:18093521
Molecular Function	GO:0042043	neurexin family protein binding	NLGN4X	IDA		Human	PMID:19726642
Molecular Function	GO:0005515	protein binding	NLGN4X	IPI	UniProtKB:P31016	Human	PMID:11368788
Molecular Function	GO:0005515	protein binding	NLGN4X	IPI	UniProtKB:Q9NY99	Human	PMID:17292328
Molecular Function	GO:0005515	protein binding	NLGN4X	IPI	UniProtKB:Q63373-3	Human	PMID:20543817
Molecular Function	GO:0005515	protein binding	NLGN4Y	IPI	UniProtKB:Q9NY99	Human	PMID:17292328
Molecular Function	GO:0042803	protein homodimerization activity	NLGN4X	IDA		Human	PMID:18093521
Molecular Function	GO:0097110	scaffold protein binding	NLGN4X	IPI	UniProtKB:P31016	Human	PMID:11368788
Molecular Function	GO:0097110	scaffold protein binding	NLGN4X	IPI	UniProtKB:Q9NY99	Human	PMID:17292328
Molecular Function	GO:0097110	scaffold protein binding	NLGN4Y	IPI	UniProtKB:Q9NY99	Human	PMID:17292328
Cellular Component	GO:0009986	cell surface	NLGN4X	IDA		Human	PMID:15150161
Cellular Component	GO:0009986	cell surface	NLGN4X	IDA		Human	PMID:17292328
Cellular Component	GO:0009986	cell surface	NLGN4X	IDA		Human	PMID:19726642
Cellular Component	GO:0030425	dendrite	NLGN4X	IDA		Human	PMID:19726642
Cellular Component	GO:0060076	excitatory synapse	NLGN4X	IDA		Human	PMID:15620359
Cellular Component	GO:0098690	glycinergic synapse	Nlgn4l	IPI		Mouse	PMID:21282647
Cellular Component	GO:0098690	glycinergic synapse	Nlgn4l	IDA		Mouse	PMID:21282647
Cellular Component	GO:0098690	glycinergic synapse	Nlgn4l	IMP		Mouse	PMID:21282647
Cellular Component	GO:0005886	plasma membrane	NLGN4X	IDA		Human	PMID:11368788
Cellular Component	GO:0005886	plasma membrane	NLGN4X	IDA		Human	PMID:19726642
Cellular Component	GO:0005886	plasma membrane	Nlgn4l	IDA		Mouse	MGI:MGI:3774711|PMID:18227507
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn4l	IDA		Mouse	PMID:21282647
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn4l	IMP		Mouse	PMID:21282647
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn4l	IPI		Mouse	PMID:21282647
Cellular Component	GO:0045202	synapse	Nlgn4l	IDA		Mouse	MGI:MGI:3774711|PMID:18227507
Biological Process	GO:0030534	adult behavior	NLGN4X	IMP		Human	PMID:12669065
Biological Process	GO:0003360	brainstem development	Nlgn4l	IMP		Mouse	MGI:MGI:3774711|PMID:18227507
Biological Process	GO:0021549	cerebellum development	Nlgn4l	IMP		Mouse	MGI:MGI:3774711|PMID:18227507
Biological Process	GO:0007612	learning	NLGN4X	IMP		Human	PMID:12669065
Biological Process	GO:0007612	learning	NLGN4Y	IMP		Human	PMID:18628683
Biological Process	GO:0008049	male courtship behavior	Nlgn4l	IMP		Mouse	MGI:MGI:3774711|PMID:18227507
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	NLGN4X	IDA		Human	PMID:19726642
Biological Process	GO:0035265	organ growth	Nlgn4l	IMP		Mouse	MGI:MGI:3774711|PMID:18227507
Biological Process	GO:0097105	presynaptic membrane assembly	NLGN4X	IDA		Human	PMID:19726642
Biological Process	GO:0035176	social behavior	NLGN4X	IMP		Human	PMID:12669065
Biological Process	GO:0035176	social behavior	NLGN4X	IMP		Human	PMID:19726642
Biological Process	GO:0035176	social behavior	NLGN4Y	IMP		Human	PMID:18628683
Biological Process	GO:0035176	social behavior	Nlgn4l	IMP	MGI:MGI:3775814	Mouse	PMID:18227507
Biological Process	GO:0050808	synapse organization	NLGN4X	IMP		Human	PMID:15150161
Biological Process	GO:0002124	territorial aggressive behavior	Nlgn4l	IMP		Mouse	MGI:MGI:3774711|PMID:18227507
Biological Process	GO:0071625	vocalization behavior	NLGN4X	IMP		Human	PMID:12669065
Biological Process	GO:0071625	vocalization behavior	NLGN4X	IMP		Human	PMID:19726642
Biological Process	GO:0071625	vocalization behavior	NLGN4Y	IMP		Human	PMID:18628683
Biological Process	GO:0071625	vocalization behavior	Nlgn4l	IMP		Mouse	MGI:MGI:3774711|PMID:18227507

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern