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Nlgn4l Gene Detail
Summary
  • Symbol
    Nlgn4l
  • Name
    neuroligin 4-like
  • Synonyms
    NL4, NL-4, Nlgn4
  • Feature Type
    protein coding gene
  • IDs
    MGI:3775191
    NCBI Gene: 100113365
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:169067543-169089017 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome XY,
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3775191
 protein coding gene ChrX:169066267-169089058 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NLGN4X, neuroligin 4 X-linked
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLGN4X, neuroligin 4 X-linked
  • Synonyms
    ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4
  • Links
    NCBI Gene ID: 57502
    neXtProt AC: NX_Q8N0W4
    UniProt: Q8N0W4

  • Chr Location
    Xp22.32-p22.31; chrX:5840637-6228867 (-)  GRCh38
  • Human Ortholog
    NLGN4Y, neuroligin 4 Y-linked
  • Synonyms
    HNL4Y
  • Links
    NCBI Gene ID: 22829
    neXtProt AC: NX_Q8NFZ3
    UniProt: Q8NFZ3

  • Chr Location
    Yq11.221; chrY:14522573-14845654 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nlgn4l mouse models; 1 with human NLGN4X associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in deficits in reciprocal social interaction and communication as well as small reduction of total brain and brain stem volume.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Literature Summary
    2
Sequences &
Gene Models
less
  • All Sequences
    35
  • RefSeq
    14
  • UniProt
    5
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000121607 Ensembl Gene Model | MGI Sequence Detail 21475 C57BL/6J ±  kb
transcript ENSMUST00000249668 Ensembl | MGI Sequence Detail 3402 Not Applicable  
polypeptide ENSMUSP00000159847 Ensembl | MGI Sequence Detail 945 Not Applicable  
For the selected sequence
Protein
Information
less
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:343246 Benner O, et al., Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms. J Biol Chem. 2023 Oct 20;299(12):105361
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory