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Nlgn4l Gene Detail
Summary
  • Symbol
    Nlgn4l
  • Name
    neuroligin 4-like
  • Synonyms
    NL4, NL-4, Nlgn4
  • Feature Type
    protein coding gene
  • IDs
    MGI:3775191
    NCBI Gene: 100113365
Location & Maps
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  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome Unknown
Human Diseases
more
  • Diseases
    1 with Nlgn4l mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Gene trapped
    1
Homozygous mutation of this gene results in deficits in reciprocal social interaction and communication as well as small reduction of total brain and brain stem volume.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
transcript EF692521 GenBank | EMBL | DDBJ | MGI Sequence Detail 3402 BALB/c  
polypeptide B0F2B4 UniProt | EBI | MGI Sequence Detail 945 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000033559 neuroligin 4-like
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR002018 Carboxylesterase, type B
    IPR019819 Carboxylesterase type B, conserved site
References
more
  • Summaries
    All 17
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:216881 Ju A, et al., Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism. Behav Brain Res. 2014 Aug 15;270:159-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory