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Nlgn4l
Gene Detail
 Symbol
Name
ID
Nlgn4l
neuroligin 4-like
MGI:3775191
Synonyms NL4, NL-4, Nlgn4
Feature Type protein coding gene
Genetic Map
Chromosome Unknown
Alleles
and
phenotypes
All alleles(1) : Gene trapped(1)
 
Homozygous mutation of this gene results in deficits in reciprocal social interaction and communication as well as small reduction of total brain and brain stem volume.
 
Human Diseases Modeled Using Mouse Nlgn4l (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process brainstem development, cerebellum development, ...
Component cell junction, cell surface, ...
Function neurexin family protein binding, receptor activity
Expression
Literature Summary: (1 records)
Other database
links
Entrez Gene100113365
UniGene468446
Sequences
Representative SequencesLengthStrain/SpeciesFlank
transcript EF692521 GenBank | EMBL | DDBJ | MGI Sequence Detail 3402 BALB/c 
polypeptide B0F2B4 UniProt | EBI | MGI Sequence Detail 945 Not Applicable 

For the selected sequences
All sequences(3) UniProt(1)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
Protein Ontology PR:000033559 neuroligin 4-like
Graphical View of Protein Domain Structure
References (Earliest) J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
(Latest) J:201709 El-Kordi A, et al., Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism. Behav Brain Res. 2013 Aug 15;251:41-9
All references(14)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory