Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTSS2
  • Mouse genes Mtss2
  • Rat genes Mtss2
  • Zfish genes mtss1la,mtss1lb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mtss2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003785	actin monomer binding	Mtss2	IDA		Mouse	PMID:18413296
Molecular Function	GO:0005096	GTPase activator activity	MTSS2	IDA		Human	PMID:20875796
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Mtss2	IDA		Mouse	PMID:18413296
Molecular Function	GO:0005515	protein binding	MTSS2	IPI	UniProtKB:P13196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MTSS2	IPI	UniProtKB:Q9H7N4	Human	PMID:32296183
Molecular Function	GO:0031267	small GTPase binding	MTSS2	IPI	UniProtKB:P63000	Human	PMID:20875796
Molecular Function	GO:0031267	small GTPase binding	Mtss2	IDA		Mouse	PMID:18413296
Cellular Component	GO:0030864	cortical actin cytoskeleton	Mtss2	IDA		Mouse	PMID:18413296
Cellular Component	GO:0030027	lamellipodium	Mtss2	IDA		Mouse	PMID:18413296
Cellular Component	GO:0005886	plasma membrane	Mtss2	IDA		Mouse	PMID:18413296
Cellular Component	GO:0001726	ruffle	Mtss2	IDA		Mouse	PMID:18413296
Cellular Component	GO:0032587	ruffle membrane	MTSS2	IDA		Human	PMID:20875796
Biological Process	GO:0090630	activation of GTPase activity	MTSS2	IDA		Human	PMID:20875796
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	MTSS2	IDA		Human	PMID:20875796
Biological Process	GO:0097581	lamellipodium organization	Mtss2	IMP		Mouse	PMID:18413296
Biological Process	GO:0061024	membrane organization	Mtss2	IDA		Mouse	PMID:18413296

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern