Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTHFR
  • Mouse genes Mthfr
  • Rat genes Mthfr
  • Zfish genes mthfr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mthfr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	MTHFR	IDA		Human	PMID:12673793
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	Mthfr	IDA		Rat	PMID:11730351|RGD:1601423
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	MTHFR	IGI	UniProtKB:P53128	Human	PMID:10551815
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	MTHFR	IDA		Human	PMID:12673793
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	MTHFR	IMP		Human	PMID:12673793
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	MTHFR	IDA		Human	PMID:24769206
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	MTHFR	IMP		Human	PMID:25736335
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	MTHFR	IDA		Human	PMID:29891918
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Mthfr	IMP	MGI:MGI:2385823	Mouse	PMID:15217352
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Mthfr	IDA		Rat	PMID:11730351|RGD:1601423
Molecular Function	GO:0072341	modified amino acid binding	MTHFR	IDA		Human	PMID:20031578
Molecular Function	GO:0050661	NADP binding	Mthfr	IDA		Rat	PMID:11730351|RGD:1601423
Molecular Function	GO:0044877	protein-containing complex binding	MTHFR	IPI	ComplexPortal:CPX-2007	Human	PMID:24769206
Cellular Component	GO:0005829	cytosol	Mthfr	IDA		Rat	PMID:1119805|RGD:6902895
Cellular Component	GO:0045202	synapse	Mthfr	IDA		Rat	PMID:1119805|RGD:6902895
Biological Process	GO:0070828	heterochromatin organization	MTHFR	IDA		Human	PMID:24769206
Biological Process	GO:0050667	homocysteine metabolic process	MTHFR	IDA		Human	PMID:20031578
Biological Process	GO:0050667	homocysteine metabolic process	Mthfr	IEP		Rat	PMID:18726220|RGD:2317121
Biological Process	GO:0009086	methionine biosynthetic process	Mthfr	IMP	MGI:MGI:2385823	Mouse	PMID:15217352
Biological Process	GO:0006555	methionine metabolic process	MTHFR	IGI	UniProtKB:P53128	Human	PMID:10551815
Biological Process	GO:0001843	neural tube closure	MTHFR	IMP		Human	PMID:25855017
Biological Process	GO:0001843	neural tube closure	MTHFR	IMP		Human	PMID:29222906
Biological Process	GO:0031060	regulation of histone methylation	MTHFR	IDA		Human	PMID:24769206
Biological Process	GO:0043200	response to amino acid	Mthfr	IEP		Rat	PMID:737254|RGD:6893691
Biological Process	GO:0051593	response to folic acid	Mthfr	IEP		Rat	PMID:15313378|RGD:6893667
Biological Process	GO:0001666	response to hypoxia	Mthfr	IEP		Rat	PMID:15845641|RGD:1359026
Biological Process	GO:0070555	response to interleukin-1	Mthfr	IEP		Rat	PMID:18726220|RGD:2317121
Biological Process	GO:0033274	response to vitamin B2	Mthfr	IEP		Rat	PMID:3676170|RGD:2317124
Biological Process	GO:0009410	response to xenobiotic stimulus	Mthfr	IEP		Rat	PMID:3088464|RGD:2317125
Biological Process	GO:0009410	response to xenobiotic stimulus	Mthfr	IEP		Rat	PMID:3606631|RGD:2317123
Biological Process	GO:0009410	response to xenobiotic stimulus	Mthfr	IEP		Rat	PMID:6355408|RGD:2317127
Biological Process	GO:0009410	response to xenobiotic stimulus	Mthfr	IEP		Rat	PMID:6388580|RGD:2317126
Biological Process	GO:0046500	S-adenosylmethionine metabolic process	Mthfr	IEP		Rat	PMID:1201245|RGD:6893692
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFR	IGI	UniProtKB:P53128	Human	PMID:10551815
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFR	IDA		Human	PMID:12673793
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFR	IMP		Human	PMID:12673793
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFR	IMP		Human	PMID:25736335
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFR	IDA		Human	PMID:29891918
Biological Process	GO:0046653	tetrahydrofolate metabolic process	Mthfr	IDA		Rat	PMID:11730351|RGD:1601423

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern