Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MPC2
  • Mouse genes Mpc2
  • Rat genes Mpc2
  • Zfish genes mpc2a,mpc2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mpc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	MPC2	IPI	UniProtKB:O95563	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:O60830	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:P02654	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q13596	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q17RD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q53QW1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q5TGZ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q6NTF9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q9NR28	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q9NZD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q9UHD4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q9Y5U8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:O00429-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:P29692-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q01658	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q8WUW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MPC2	IPI	UniProtKB:Q9Y5Q9	Human	PMID:32814053
Molecular Function	GO:0050833	pyruvate transmembrane transporter activity	Mpc2	IDA		Mouse	PMID:22628554
Molecular Function	GO:0050833	pyruvate transmembrane transporter activity	Mpc2	IGI	MGI:MGI:1915240	Mouse	PMID:22628554
Cellular Component	GO:0005743	mitochondrial inner membrane	MPC2	IDA		Human	PMID:26253029
Cellular Component	GO:0005743	mitochondrial inner membrane	Mpc2	IDA		Mouse	PMID:22628554
Cellular Component	GO:0005739	mitochondrion	MPC2	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005739	mitochondrion	Mpc2	IDA		Mouse	MGI:MGI:2682130|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Mpc2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Mpc2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005634	nucleus	MPC2	HDA		Human	PMID:21630459
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Mpc2	IMP		Mouse	PMID:22628558
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Mpc2	IMP	MGI:MGI:5635078	Mouse	PMID:24910426
Biological Process	GO:0006850	mitochondrial pyruvate transmembrane transport	MPC2	IDA		Human	PMID:26253029
Biological Process	GO:0006850	mitochondrial pyruvate transmembrane transport	MPC2	IDA		Human	PMID:27317664
Biological Process	GO:0006850	mitochondrial pyruvate transmembrane transport	MPC2	IDA		Human	PMID:29472561
Biological Process	GO:0006850	mitochondrial pyruvate transmembrane transport	Mpc2	IGI	MGI:MGI:1915240	Mouse	PMID:22628554
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Mpc2	IMP	MGI:MGI:5635078	Mouse	PMID:24910426

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern