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Mpc2 Gene Detail
Summary
  • Symbol
    Mpc2
  • Name
    mitochondrial pyruvate carrier 2
  • Synonyms
    0610006C01Rik, 2010002I07Rik, 2610205H19Rik, Brp44, ESTM43
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917706
    NCBI Gene: 70456
  • Gene Overview
    MyGene.info: MPC2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165461208-165481214 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.80 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917706
protein coding gene Chr1:165460637-165481214 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016693
protein coding gene Chr1:170947136-170975208 (+)
A/J MGP_AJ_G0016674
protein coding gene Chr1:163970620-163991647 (+)
AKR/J MGP_AKRJ_G0016640
protein coding gene Chr1:168932067-168952597 (+)
BALB/cJ MGP_BALBcJ_G0016635
protein coding gene Chr1:164466106-164486965 (+)
C3H/HeJ MGP_C3HHeJ_G0016459
protein coding gene Chr1:169152054-169173351 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017096
protein coding gene Chr1:176680316-176701976 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014805
protein coding gene Chr1:155870041-155890472 (+)
CAST/EiJ MGP_CASTEiJ_G0016039
protein coding gene Chr1:168769665-168794120 (+)
CBA/J MGP_CBAJ_G0016434
protein coding gene Chr1:182955431-182982356 (+)
DBA/2J MGP_DBA2J_G0016540
protein coding gene Chr1:162855019-162877892 (+)
FVB/NJ MGP_FVBNJ_G0016538
protein coding gene Chr1:161294795-161318311 (+)
LP/J MGP_LPJ_G0016611
protein coding gene Chr1:172004599-172024999 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016563
protein coding gene Chr1:190458398-190480162 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017132
protein coding gene Chr1:168792597-168813131 (+)
PWK/PhJ MGP_PWKPhJ_G0015825
protein coding gene Chr1:162060298-162081170 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015612
protein coding gene Chr1:167636977-167660611 (+)
WSB/EiJ MGP_WSBEiJ_G0016101
protein coding gene Chr1:168947551-168968069 (+)



Homology
more
  • Human Ortholog
    MPC2, mitochondrial pyruvate carrier 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPC2, mitochondrial pyruvate carrier 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRP44, SLC54A2
  • Links
    NCBI Gene ID: 25874
    neXtProt AC: NX_O95563
    UniProt: O95563

  • Chr Location
    1q24.2; chr1:167916675-167937069 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die during organogenesis. Mice homozygous for a truncated allele display defects in mitochondrial physiology and impaired glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70456 NCBI Gene Model | MGI Sequence Detail 20007 C57BL/6J ±  kb
    transcript NM_027430 RefSeq | MGI Sequence Detail 854 C57BL/6  
    polypeptide Q9D023 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1334431, MGI:1915570, MGI:1919298
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:255591 Chen Y, et al., Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid. Endocrinology. 2018 Feb 1;159(2):609-621

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory