Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MLST8
  • Mouse genes Mlst8
  • Rat genes Mlst8
  • Zfish genes mlst8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mlst8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:P42345	Human	PMID:12408816
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:Q8N122	Human	PMID:12408816
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:P42345	Human	PMID:17461779
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:P42345	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:Q8N122	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:Q6R327	Human	PMID:24036451
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:Q8N122	Human	PMID:24036451
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:P42345	Human	PMID:26348909
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:Q6P9B6	Human	PMID:29750193
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:Q9Y2K2	Human	PMID:30232230
Molecular Function	GO:0005515	protein binding	MLST8	IPI	UniProtKB:Q9NVC3	Human	PMID:35561222
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	MLST8	IDA		Human	PMID:12718876
Cellular Component	GO:0005737	cytoplasm	Mlst8	IDA		Rat	PMID:11182770|RGD:68781
Cellular Component	GO:0005829	cytosol	Mlst8	IDA		Rat	PMID:11182770|RGD:68781
Cellular Component	GO:0031931	TORC1 complex	MLST8	IPI		Human	PMID:26678875
Cellular Component	GO:0031931	TORC1 complex	MLST8	IDA		Human	PMID:12718876
Cellular Component	GO:0031931	TORC1 complex	MLST8	IDA		Human	PMID:24036451
Cellular Component	GO:0031931	TORC1 complex	Mlst8	IDA		Mouse	MGI:MGI:5816448|PMID:12718876
Cellular Component	GO:0031932	TORC2 complex	MLST8	IPI		Human	PMID:17461779
Cellular Component	GO:0031932	TORC2 complex	MLST8	IDA		Human	PMID:24036451
Biological Process	GO:0016310	phosphorylation	MLST8	IDA		Human	PMID:19299511
Biological Process	GO:0016310	phosphorylation	MLST8	IDA		Human	PMID:29567957
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Mlst8	IMP		Mouse	PMID:15467718
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Mlst8	IMP		Mouse	PMID:15467718
Biological Process	GO:0032008	positive regulation of TOR signaling	MLST8	IMP		Human	PMID:15467718
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	MLST8	IMP		Human	PMID:15467718
Biological Process	GO:0043087	regulation of GTPase activity	Mlst8	IMP		Mouse	PMID:15467718
Biological Process	GO:0038202	TORC1 signaling	MLST8	IMP		Human	PMID:12718876

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern