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Mlst8
Gene Detail
 Symbol
Name
ID
Mlst8
MTOR associated protein, LST8 homolog (S. cerevisiae)
MGI:1929514
Synonyms 0610033N12Rik, Gbl, mLST8
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:24473550-24479078 bp, - strand
From NCBI annotation of GRCm38

  5529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mlst8

Human
homologs
Human Homolog MLST8, MTOR associated protein, LST8 homolog (S. cerevisiae)
NCBI Gene ID 64223
neXtProt AC  NX_Q9BVC4
Human Synonyms  GbetaL, GBL, LST8, POP3, WAT1
Human Chr (Location)  16p13.3; chr16:2205177-2209417 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(7) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation exhibit lethality around E10.5 and abnormal yolk sac vasculature, brain development and heart development.
 
Interactions
Mlst8 interacts with 243 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process positive regulation of actin filament polymerization, positive regulation of peptidyl-tyrosine phosphorylation, ...
Component cytoplasm, cytosol, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 29
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024142 (Evidence)
Entrez Gene56716 (Evidence)
DoTSDT.101384756, DT.101737186, DT.101737187, DT.489505, DT.87041782, DT.91404644
Consensus CDS ProjectCCDS28484.1
International Mouse Knockout Project StatusMlst8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56716 NCBI Gene Model | MGI Sequence Detail 5529 C57BL/6J ±  kb
transcript NM_001252463 RefSeq | MGI Sequence Detail 3366 C57BL/6 
polypeptide Q9DCJ1 UniProt | EBI | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(1)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000009971 target of rapamycin complex subunit LST8
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184787 Kaur S, et al., Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7723-8
All references(38)
Other
accession IDs
MGI:1917593, MGI:2146758, MGI:2146886, MGI:2146940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory