Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MLC1
  • Mouse genes Mlc1
  • Rat genes Mlc1
  • Zfish genes mlc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mlc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	MLC1	IPI	UniProtKB:Q15049	Human	PMID:15367490
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P78508	Human	PMID:17628813
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:B5DFL0	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:D4A772	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P49655	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P49817	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P51636	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P68370	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P78508	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q03135	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q13424	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q9Y4J8	Human	PMID:19931615
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P05026	Human	PMID:22328087
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P04792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P07196	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q00403	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q01658	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q9UBB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MLC1	IPI	UniProtKB:Q9Y5Q9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Mlc1	IPI	PR:Q640R3	Mouse	PMID:21419380
Molecular Function	GO:0044877	protein-containing complex binding	MLC1	IDA		Human	PMID:17628813
Cellular Component	GO:0016324	apical plasma membrane	Mlc1	IDA		Mouse	MGI:MGI:3512710|PMID:15367490
Cellular Component	GO:0097450	astrocyte end-foot	Mlc1	IDA		Mouse	MGI:MGI:3512710|PMID:15367490
Cellular Component	GO:0016323	basolateral plasma membrane	MLC1	IDA		Human	PMID:18165104
Cellular Component	GO:0005901	caveola	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0005911	cell-cell junction	Mlc1	IDA		Mouse	MGI:MGI:3512710|PMID:15367490
Cellular Component	GO:0005911	cell-cell junction	mlc1	IDA		Zfish	PMID:24824219
Cellular Component	GO:0005737	cytoplasm	MLC1	IDA		Human	PMID:15892299
Cellular Component	GO:0031410	cytoplasmic vesicle	MLC1	IDA		Human	PMID:15892299
Cellular Component	GO:0031410	cytoplasmic vesicle	MLC1	IDA		Human	PMID:19931615
Cellular Component	GO:0031410	cytoplasmic vesicle	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0005829	cytosol	MLC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005769	early endosome	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0005783	endoplasmic reticulum	MLC1	IDA		Human	PMID:15367490
Cellular Component	GO:0005783	endoplasmic reticulum	MLC1	IDA		Human	PMID:22328087
Cellular Component	GO:0005783	endoplasmic reticulum	Mlc1	IDA		Mouse	MGI:MGI:3512710|PMID:15367490
Cellular Component	GO:0005783	endoplasmic reticulum	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0005768	endosome	MLC1	IDA		Human	PMID:18165104
Cellular Component	GO:0005764	lysosome	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0016020	membrane	MLC1	IDA		Human	PMID:17628813
Cellular Component	GO:0045121	membrane raft	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MLC1	IDA		Human	PMID:19931615
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MLC1	IDA		Human	PMID:22328087
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0005886	plasma membrane	MLC1	IDA		Human	PMID:15367490
Cellular Component	GO:0005886	plasma membrane	MLC1	IDA		Human	PMID:15892299
Cellular Component	GO:0005886	plasma membrane	MLC1	IDA		Human	PMID:22328087
Cellular Component	GO:0005886	plasma membrane	Mlc1	IDA		Mouse	MGI:MGI:3512710|PMID:15367490
Cellular Component	GO:0005886	plasma membrane	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Cellular Component	GO:0055037	recycling endosome	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Biological Process	GO:0072584	caveolin-mediated endocytosis	Mlc1	IMP		Rat	PMID:19931615|RGD:2326037
Biological Process	GO:0071397	cellular response to cholesterol	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Biological Process	GO:0032388	positive regulation of intracellular transport	MLC1	IDA		Human	PMID:19931615
Biological Process	GO:0034394	protein localization to cell surface	mlc1	IMP	ZFIN:ZDB-GENO-141217-17	Zfish	PMID:24824219
Biological Process	GO:0015031	protein transport	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037
Biological Process	GO:0047484	regulation of response to osmotic stress	MLC1	IMP		Human	PMID:22328087
Biological Process	GO:0016192	vesicle-mediated transport	Mlc1	IDA		Rat	PMID:19931615|RGD:2326037

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern