Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MKNK1
  • Mouse genes Mknk1
  • Rat genes Mknk1
  • Zfish genes mknk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mknk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MKNK1	IDA		Human	PMID:9155018
Molecular Function	GO:0005524	ATP binding	Mknk1	IDA		Mouse	MGI:MGI:87363|PMID:9155017
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:Q16539	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:Q16539	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:Q16539	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:P28482	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:P28482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:Q03060-25	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:P28482	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:Q16539	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MKNK1	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MKNK1	IDA		Human	PMID:17130135
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MKNK1	IDA		Human	PMID:9155018
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mknk1	IDA		Mouse	MGI:MGI:87363|PMID:9155017
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mknk1	IMP		Rat	PMID:16955078|RGD:8553011
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mknk1	IMP		Rat	PMID:17510413|RGD:8553009
Cellular Component	GO:0005654	nucleoplasm	MKNK1	IDA		Human	GO_REF:0000052
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Mknk1	IMP	MGI:MGI:3052673	Mouse	PMID:17903173
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Mknk1	IGI	MGI:MGI:894279	Mouse	PMID:17903173
Biological Process	GO:0035556	intracellular signal transduction	MKNK1	IDA		Human	PMID:9155018
Biological Process	GO:0035556	intracellular signal transduction	Mknk1	IDA		Mouse	MGI:MGI:87363|PMID:9155017
Biological Process	GO:0018105	peptidyl-serine phosphorylation	MKNK1	IDA		Human	PMID:17130135
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Mknk1	IMP		Rat	PMID:16955078|RGD:8553011
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Mknk1	IMP		Rat	PMID:17510413|RGD:8553009
Biological Process	GO:0006468	protein phosphorylation	MKNK1	IDA		Human	PMID:9155018
Biological Process	GO:0006468	protein phosphorylation	Mknk1	IDA		Mouse	MGI:MGI:87363|PMID:9155017
Biological Process	GO:0006446	regulation of translational initiation	Mknk1	IMP		Rat	PMID:16955078|RGD:8553011
Biological Process	GO:0006446	regulation of translational initiation	Mknk1	IMP		Rat	PMID:17510413|RGD:8553009
Biological Process	GO:0009651	response to salt stress	Mknk1	IDA		Mouse	MGI:MGI:87363|PMID:9155017

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern