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Mknk1 Gene Detail
Summary
  • Symbol
    Mknk1
  • Name
    MAP kinase-interacting serine/threonine kinase 1
  • Synonyms
    2410048M24Rik, Mnk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:894316
    NCBI Gene: 17346
  • Gene Overview
    MyGene.info: MKNK1
Location & Maps
more
  • Sequence Map
    Chr4:115839198-115879250 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40053 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.06 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MKNK1, MAP kinase interacting serine/threonine kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MKNK1, MAP kinase interacting serine/threonine kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MNK1
  • Links
    NCBI Gene ID: 8569
    neXtProt AC: NX_Q9BUB5

  • Chr Location
    1p33; chr1:46557407-46604294 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37838
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MKNK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    19 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Mknk1
  • Incidental Mutations
    APF
Homozygous null mice are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008696 VEGA Gene Model | MGI Sequence Detail 40053 C57BL/6J ±  kb
transcript OTTMUST00000019725 VEGA | MGI Sequence Detail 2543 Not Applicable  
polypeptide OTTMUSP00000009040 VEGA | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    220 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000010429 MAP kinase-interacting serine/threonine-protein kinase 1
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 62
    cDNA 61
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1920925
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:40024 Waskiewicz AJ, et al., Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997 Apr 15;16(8):1909-20
  • Latest
    J:221371 Beggs JE, et al., The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding. Biochem J. 2015 Apr 1;467(1):63-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory