Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MKI67
  • Mouse genes Mki67
  • Rat genes Mki67
  • Zfish genes mki67
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mki67

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MKI67	IPI	UniProtKB:Q9NS87	Human	PMID:10878014
Molecular Function	GO:0005515	protein binding	MKI67	IPI	UniProtKB:Q9BYG3	Human	PMID:11342549
Molecular Function	GO:0005515	protein binding	MKI67	IPI	UniProtKB:Q9BYG3	Human	PMID:16244663
Molecular Function	GO:0005515	protein binding	MKI67	IPI	UniProtKB:Q9BQA5	Human	PMID:17577209
Molecular Function	GO:0005515	protein binding	MKI67	IPI	UniProtKB:Q9BYG3	Human	PMID:26949251
Molecular Function	GO:0003723	RNA binding	MKI67	HDA		Human	PMID:22658674
Cellular Component	GO:0005694	chromosome	MKI67	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000775	chromosome, centromeric region	Mki67	IDA		Mouse	PMID:12355204
Cellular Component	GO:0000793	condensed chromosome	MKI67	IDA		Human	PMID:27362226
Cellular Component	GO:0000793	condensed chromosome	Mki67	IDA		Mouse	PMID:12355204
Cellular Component	GO:0005737	cytoplasm	Mki67	IDA		Mouse	PMID:11731231
Cellular Component	GO:0016020	membrane	MKI67	HDA		Human	PMID:19946888
Cellular Component	GO:0016604	nuclear body	MKI67	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	MKI67	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	MKI67	IDA		Human	PMID:17577209
Cellular Component	GO:0005730	nucleolus	Mki67	IDA		Mouse	PMID:15237214
Cellular Component	GO:0005730	nucleolus	Mki67	IDA		Mouse	PMID:12355204
Cellular Component	GO:0005654	nucleoplasm	MKI67	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MKI67	IDA		Human	PMID:22378020
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:28811219
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:23786676
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:15237214
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:23284756
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:19409883
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:25433207
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:18604197
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:24582971
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:24191021
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:17257418
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:22984613
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:21464233
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Mouse	PMID:16314515
Cellular Component	GO:0005634	nucleus	Mki67	IDA		Rat	PMID:12368262|RGD:10047140
Biological Process	GO:0031100	animal organ regeneration	Mki67	IEP		Rat	PMID:9303485|RGD:2317713
Biological Process	GO:0008283	cell population proliferation	Mki67	IDA		Mouse	PMID:12972605
Biological Process	GO:0008283	cell population proliferation	Mki67	IEP		Rat	PMID:2476477|RGD:2317712
Biological Process	GO:0034605	cellular response to heat	Mki67	IEP		Rat	PMID:9631633|RGD:2317714
Biological Process	GO:1990705	cholangiocyte proliferation	Mki67	IDA		Mouse	PMID:25446530
Biological Process	GO:0006259	DNA metabolic process	Mki67	IEP		Rat	PMID:9303485|RGD:2317713
Biological Process	GO:0050673	epithelial cell proliferation	Mki67	IDA		Mouse	PMID:33129760
Biological Process	GO:0050673	epithelial cell proliferation	Mki67	IDA		Mouse	PMID:19303854
Biological Process	GO:0072574	hepatocyte proliferation	Mki67	IDA		Mouse	PMID:25446530
Biological Process	GO:0051321	meiotic cell cycle	Mki67	IDA		Mouse	PMID:12355204
Biological Process	GO:1902275	regulation of chromatin organization	Mki67	IMP		Mouse	MGI:MGI:5796066|PMID:26949251
Biological Process	GO:0051983	regulation of chromosome segregation	MKI67	IDA		Human	PMID:27362226
Biological Process	GO:0007088	regulation of mitotic nuclear division	MKI67	IDA		Human	PMID:27362226
Biological Process	GO:0014070	response to organic cyclic compound	Mki67	IEP		Rat	PMID:16987298|RGD:7240698
Biological Process	GO:0072089	stem cell proliferation	Mki67	IDA		Mouse	PMID:19303854

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern