Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MED6
  • Mouse genes Med6
  • Rat genes Med6
  • Zfish genes med6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Med6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Med6	IDA		Mouse	PMID:18722179
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9NX70	Human	PMID:14576168
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9NX70	Human	PMID:15175163
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q13616	Human	PMID:22479149
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q6P2C8	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9BUE0	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9D7W5	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9NVC6	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9NX70	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9R0X0	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9BUE0	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MED6	IPI	UniProtKB:Q9BUE0	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Med6	IPI	PR:Q9DBS2	Mouse	PMID:11591653
Molecular Function	GO:0003713	transcription coactivator activity	MED6	IDA		Human	PMID:12037571
Molecular Function	GO:0001223	transcription coactivator binding	MED6	IPI	UniProtKB:Q71SY5	Human	PMID:17641689
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Med6	IDA		Rat	PMID:12149480|RGD:2304264
Cellular Component	GO:0070847	core mediator complex	MED6	IPI		Human	PMID:24882805
Cellular Component	GO:0016592	mediator complex	MED6	IDA		Human	PMID:12037571
Cellular Component	GO:0016592	mediator complex	MED6	IDA		Human	PMID:14638676
Cellular Component	GO:0016592	mediator complex	MED6	IMP		Human	PMID:17641689
Cellular Component	GO:0016592	mediator complex	Med6	IDA		Mouse	PMID:15340084
Cellular Component	GO:0016020	membrane	MED6	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	MED6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MED6	IDA		Human	PMID:24882805
Cellular Component	GO:0005634	nucleus	Med6	IDA		Mouse	PMID:18722179
Cellular Component	GO:0000151	ubiquitin ligase complex	Med6	IDA		Rat	PMID:12149480|RGD:2304264
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MED6	IDA		Human	PMID:12037571
Biological Process	GO:0016567	protein ubiquitination	Med6	IDA		Rat	PMID:12149480|RGD:2304264
Biological Process	GO:0035019	somatic stem cell population maintenance	Med6	IMP		Mouse	PMID:20720539

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern