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Med6 Gene Detail
Summary
  • Symbol
    Med6
  • Name
    mediator complex subunit 6
  • Synonyms
    1500012F11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917042
    NCBI Gene: 69792
  • Gene Overview
    MyGene.info: MED6
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81573557-81595008 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.80 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917042
protein coding gene Chr12:81573557-81595066 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019905
protein coding gene Chr12:82046645-82072421 (-)
A/J MGP_AJ_G0019862
protein coding gene Chr12:79048215-79067916 (-)
AKR/J MGP_AKRJ_G0019838
protein coding gene Chr12:81194772-81214694 (-)
BALB/cJ MGP_BALBcJ_G0019842
protein coding gene Chr12:79272799-79290871 (-)
C3H/HeJ MGP_C3HHeJ_G0019648
protein coding gene Chr12:81657232-81677771 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020294
protein coding gene Chr12:84433765-84455194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017911
protein coding gene Chr12:76018145-76036166 (-)
CAST/EiJ MGP_CASTEiJ_G0019197
protein coding gene Chr12:76545103-76564890 (-)
CBA/J MGP_CBAJ_G0019619
protein coding gene Chr12:87701702-87728077 (-)
DBA/2J MGP_DBA2J_G0019734
protein coding gene Chr12:78626289-78646091 (-)
FVB/NJ MGP_FVBNJ_G0019720
protein coding gene Chr12:77475014-77496488 (-)
LP/J MGP_LPJ_G0019806
protein coding gene Chr12:81954596-81986998 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019759
protein coding gene Chr12:90712214-90730182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020328
protein coding gene Chr12:80724583-80743364 (-)
PWK/PhJ MGP_PWKPhJ_G0018962
protein coding gene Chr12:73035167-73052161 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018756
protein coding gene Chr12:75244628-75260894 (-)
WSB/EiJ MGP_WSBEiJ_G0019249
protein coding gene Chr12:81372458-81394825 (-)



Homology
more
  • Human Ortholog
    MED6, mediator complex subunit 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED6, mediator complex subunit 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARC33, NY-REN-28
  • Links
    NCBI Gene ID: 10001
    neXtProt AC: NX_O75586
    UniProt: O75586

  • Chr Location
    14q24.2; chr14:70583221-70600690 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002679 Ensembl Gene Model | MGI Sequence Detail 21452 C57BL/6J ±  kb
transcript ENSMUST00000161211 Ensembl | MGI Sequence Detail 1059 Not Applicable  
polypeptide ENSMUSP00000125156 Ensembl | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR038566 Med6 core domain superfamily
    IPR007018 Mediator complex, subunit Med6
    IPR016820 Mediator complex, subunit Med6, metazoa/plant
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 11
Other
Accession IDs
less
MGI:2144950, MGI:2144985
References
more
  • Summaries
    All 44
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:239012 Aranda-Orgilles B, et al., MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016 Dec 01;19(6):784-799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory