Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ME1
  • Mouse genes Me1
  • Rat genes Me1
  • Zfish genes me1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Me1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	ME1	IPI	UniProtKB:P48163	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	ME1	IPI	UniProtKB:P48163	Human	PMID:34547241
Molecular Function	GO:0000287	magnesium ion binding	ME1	IDA		Human	PMID:7757881
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	ME1	IDA		Human	PMID:7757881
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	ME1	IDA		Human	PMID:8187880
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	ME1	IDA		Human	PMID:8804575
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	Me1	IDA		Mouse	PMID:6838491
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	Me1	IMP		Mouse	PMID:18802677
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	Me1	IDA		Rat	PMID:2416344|RGD:8554490
Molecular Function	GO:0004470	malic enzyme activity	ME1	IMP		Human	PMID:23334421
Molecular Function	GO:0004470	malic enzyme activity	ME1	IDA		Human	PMID:7622060
Molecular Function	GO:0004470	malic enzyme activity	ME1	IDA		Human	PMID:8187880
Molecular Function	GO:0004470	malic enzyme activity	Me1	IDA		Rat	PMID:11735100|RGD:2317316
Molecular Function	GO:0004470	malic enzyme activity	Me1	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0004470	malic enzyme activity	Me1	IDA		Rat	PMID:18062843|RGD:2317315
Molecular Function	GO:0030145	manganese ion binding	ME1	IDA		Human	PMID:7622060
Molecular Function	GO:0030145	manganese ion binding	ME1	IDA		Human	PMID:7757881
Molecular Function	GO:0030145	manganese ion binding	ME1	IDA		Human	PMID:8804575
Molecular Function	GO:0050661	NADP binding	Me1	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0008948	oxaloacetate decarboxylase activity	ME1	IDA		Human	PMID:7757881
Molecular Function	GO:0005515	protein binding	ME1	IPI	UniProtKB:P11498	Human	PMID:34547241
Molecular Function	GO:0005515	protein binding	Me1	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Cellular Component	GO:0005737	cytoplasm	ME1	IDA		Human	PMID:34547241
Cellular Component	GO:0005829	cytosol	Me1	IDA		Rat	PMID:2416344|RGD:8554490
Cellular Component	GO:0005739	mitochondrion	Me1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Me1	IDA		Rat	PMID:9681477|RGD:10047338
Biological Process	GO:0006108	malate metabolic process	ME1	IDA		Human	PMID:7622060
Biological Process	GO:0006108	malate metabolic process	ME1	IDA		Human	PMID:8187880
Biological Process	GO:0006734	NADH metabolic process	ME1	IDA		Human	PMID:34547241
Biological Process	GO:0006739	NADP metabolic process	ME1	IDA		Human	PMID:34547241
Biological Process	GO:0051289	protein homotetramerization	ME1	IDA		Human	PMID:7757881
Biological Process	GO:1902031	regulation of NADP metabolic process	ME1	IMP		Human	PMID:23334421
Biological Process	GO:0009725	response to hormone	Me1	IDA		Rat	PMID:2416344|RGD:8554490

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern