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Me1 Gene Detail
Summary
  • Symbol
    Me1
  • Name
    malic enzyme 1, NADP(+)-dependent, cytosolic
  • Synonyms
    D9Ertd267e, Mdh-1, Mod1, Mod-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97043
    NCBI Gene: 17436
  • Gene Overview
    MyGene.info: ME1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:86581371-86695953 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114583 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 46.58 cM
  • Mapping Data
    149 experiments
Homology
more
  • Human Ortholog
    ME1, malic enzyme 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ME1, malic enzyme 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUMNDME, MES
  • Links
    NCBI Gene ID: 4199
    neXtProt AC: NX_P48163
    UniProt: P48163

  • Chr Location
    6q14.2; chr6:83210389-83431219 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit decreased body weight on a medium fat diet, altered cytoplasmic malic enzyme activity, and a male-specific reduction in food intake on a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000045046 VEGA Gene Model | MGI Sequence Detail 114583 C57BL/6J ±  kb
    transcript OTTMUST00000118380 VEGA | MGI Sequence Detail 3288 Not Applicable  
    polypeptide OTTMUSP00000066082 VEGA | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      1186 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 186
      cDNA 181
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12164, MGD-MRK-12341, MGD-MRK-12345, MGI:1098755
    References
    more
    • Summaries
      All 172
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:20246 Henderson NS, Isozymes and genetic control of NADP-malate dehydrogenase in mice. Arch Biochem Biophys. 1966 Oct;117(1):28-33
    • Latest
      J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory