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Me1
Gene Detail
Symbol

Name
ID
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
MGI:97043
Synonyms
D9Ertd267e, Mdh-1, Mod1, Mod-1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
46.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(149)
Sequence Map
Chr9:86581371-86695953 bp, - strand
From VEGA annotation of GRCm38

  114583 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ME1
Protein SuperFamily: malic enzyme
Gene Tree: Me1

Human
homologs
ME1, malic enzyme 1, NADP(+)-dependent, cytosolic
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4199
neXtProt AC: NX_P48163

Human Synonyms: HUMNDME, MES

Human Chr (Location): 6q12; chr6:83210389-83431741 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele exhibit decreased body weight on a medium fat diet, altered cytoplasmic malic enzyme activity, and a male-specific reduction in food intake on a high fat diet.
 
Interactions
Me1 interacts with 218 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (131)    Tissues (106)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
RT-PCR 8
cDNA source data(181)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase me1    NEW 
Molecular
reagents
All nucleic(186) cDNA(181) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000045046 (Evidence)
Ensembl Gene Model ENSMUSG00000032418 (Evidence)
Entrez Gene 17436 (Evidence)
UniGene 148155
DFCI TC1572265, TC1705541
DoTS DT.101195705, DT.101393041, DT.495724, DT.97341028
EC 1.1.1.39, 1.1.1.40
Consensus CDS Project CCDS23383.1, CCDS81047.1
International Mouse Phenotyping Consortium Status Me1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045046 VEGA Gene Model | MGI Sequence Detail 114583 C57BL/6J ±  kb
transcript OTTMUST00000118380 VEGA | MGI Sequence Detail 3288 Not Applicable 
polypeptide OTTMUSP00000066082 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(6)
Polymorphisms
All PCR and RFLP(6) : PCR(4) RFLP(2) SNPs within 2kb(1201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015884 Malic enzyme, conserved site
InterPro IPR012302 Malic enzyme, NAD-binding
InterPro IPR012301 Malic enzyme, N-terminal domain
InterPro IPR001891 Malic oxidoreductase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000010273 NADP-dependent malic enzyme
References
(Earliest) J:20212 Henderson NS, Research News: NADP-malate dehydrogenase ('malic') enzyme. Mouse News Lett. 1966;34:32-33
(Latest) J:194552 Jiang P, et al., Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. 2013 Jan 31;493(7434):689-93
All references(166)
Other
accession IDs
MGD-MRK-12164, MGD-MRK-12341, MGD-MRK-12345, MGI:1098755

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory