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Me1
Gene Detail
 Symbol
Name
ID
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
MGI:97043
Synonyms D9Ertd267e, Mdh-1, Mod1, Mod-1
Feature Type protein coding gene
Genetic Map
Chromosome 9
46.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(149)
Sequence Map
Chr9:86581371-86695953 bp, - strand
From VEGA annotation of GRCm38

  114583 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: malic enzyme
Gene Tree: Me1

Human
homologs
Human Homolog ME1, malic enzyme 1, NADP(+)-dependent, cytosolic
NCBI Gene ID 4199
neXtProt AC  NX_P48163
Human Synonyms  HUMNDME, MES
Human Chr (Location)  6q12; chr6:83210389-83431219 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele exhibit decreased body weight on a medium fat diet, altered cytoplasmic malic enzyme activity, and a male-specific reduction in food intake on a high fat diet.
 
Interactions
Me1 interacts with 218 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process malate metabolic process, oxidation-reduction process, ...
Component cytoplasm, cytosol, ...
Function malate dehydrogenase (decarboxylating) (NAD+) activity, malate dehydrogenase (decarboxylating) (NADP+) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (131)    Tissues (106)    Images (29)
Theiler Stages: 11, 21, 22, 23
Assay TypeResults
RNA in situ 123
RT-PCR 8
cDNA source data(181)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(186) cDNA(181) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000045046 (Evidence)
Ensembl Gene ModelENSMUSG00000032418 (Evidence)
Entrez Gene17436 (Evidence)
UniGene148155
DFCITC1572265, TC1705541
DoTSDT.101195705, DT.101393041, DT.495724, DT.97341028
EC1.1.1.39, 1.1.1.40
Consensus CDS ProjectCCDS23383.1
International Mouse Knockout Project StatusMe1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045046 VEGA Gene Model | MGI Sequence Detail 114583 C57BL/6J ±  kb
transcript OTTMUST00000118380 VEGA | MGI Sequence Detail 3288 Not Applicable 
polypeptide OTTMUSP00000066082 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(6)
Polymorphisms All PCR and RFLP(6) : PCR(4) RFLP(2) SNPs within 2kb(1201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015884 Malic enzyme, conserved site
InterPro IPR012302 Malic enzyme, NAD-binding
InterPro IPR012301 Malic enzyme, N-terminal
InterPro IPR001891 Malic oxidoreductase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000010273 NADP-dependent malic enzyme
References (Earliest) J:20212 Henderson NS, Research News: NADP-malate dehydrogenase ('malic') enzyme. Mouse News Lett. 1966;34:32-33
(Latest) J:194552 Jiang P, et al., Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. 2013 Jan 31;493(7434):689-93
All references(172)
Other
accession IDs
MGD-MRK-12164, MGD-MRK-12341, MGD-MRK-12345, MGI:1098755

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory