Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MDM4
  • Mouse genes Mdm4
  • Rat genes Mdm4
  • Zfish genes mdm4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mdm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	MDM4	IPI	UniProtKB:O75604	Human	PMID:19838211
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:O15350	Human	PMID:10469568
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:10608892
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q00987	Human	PMID:10608892
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P03255-2	Human	PMID:15604276
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:15604276
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q00987	Human	PMID:15604276
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:15916963
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q93009	Human	PMID:15916963
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P62258	Human	PMID:16227609
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P06400	Human	PMID:16510145
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P48729	Human	PMID:16511560
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P61981	Human	PMID:16511560
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P62258	Human	PMID:16511560
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P63104	Human	PMID:16511560
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q3YBA8	Human	PMID:16511560
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P61981	Human	PMID:16511572
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q3YBA8	Human	PMID:16511572
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:17080083
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P48729	Human	PMID:17110929
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q00987	Human	PMID:17159902
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:17875722
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P62258	Human	PMID:18356162
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q00987	Human	PMID:18566590
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q93009	Human	PMID:18566590
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:19255450
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:19521340
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P10415	Human	PMID:19521340
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:20515689
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:20705607
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P62837	Human	PMID:20705607
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q00987	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q00987	Human	PMID:22493164
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q13064	Human	PMID:22493164
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q00987	Human	PMID:22902369
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:24667498
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:O95971	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q7Z479	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q9Y4L5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04637	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:A0A0S2Z6X0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q13064	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P04271	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P23297	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P29034	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P33763	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:O14972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:O95971	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P41227	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:P61964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q13064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q9BRR0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q9NX04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDM4	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Mdm4	IPI	UniProtKB:P23804-1|UniProtKB:P23804-2|UniProtKB:Q93009	Mouse	MGI:MGI:4943791|PMID:20697359
Molecular Function	GO:0005515	protein binding	Mdm4	IPI	UniProtKB:Q93009	Mouse	MGI:MGI:5493215|PMID:15916963
Cellular Component	GO:0005654	nucleoplasm	MDM4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0017053	transcription repressor complex	MDM4	IPI		Human	PMID:18677113
Cellular Component	GO:0017053	transcription repressor complex	MDM4	IPI		Human	PMID:8875929
Biological Process	GO:0003283	atrial septum development	Mdm4	IGI	MGI:MGI:96952	Mouse	PMID:22821713
Biological Process	GO:0003181	atrioventricular valve morphogenesis	Mdm4	IGI	MGI:MGI:96952	Mouse	PMID:22821713
Biological Process	GO:0071456	cellular response to hypoxia	MDM4	IEP		Human	PMID:20810912
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	MDM4	IEP		Human	PMID:14660608
Biological Process	GO:0003203	endocardial cushion morphogenesis	Mdm4	IGI	MGI:MGI:96952	Mouse	PMID:22821713
Biological Process	GO:0003170	heart valve development	Mdm4	IGI	MGI:MGI:96952	Mouse	PMID:22821713
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	MDM4	IDA		Human	PMID:9271120
Biological Process	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Mdm4	IMP		Mouse	MGI:MGI:2182884|PMID:12101245
Biological Process	GO:0042177	negative regulation of protein catabolic process	MDM4	IMP		Human	PMID:10608892
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MDM4	IDA		Human	PMID:9226370
Biological Process	GO:0008284	positive regulation of cell population proliferation	Mdm4	IMP	MGI:MGI:1861977	Mouse	PMID:14712235
Biological Process	GO:0050821	protein stabilization	MDM4	IEP		Human	PMID:10608892
Biological Process	GO:0065003	protein-containing complex assembly	MDM4	IDA		Human	PMID:10608892
Biological Process	GO:0002027	regulation of heart rate	Mdm4	IGI	MGI:MGI:96952	Mouse	PMID:22821713
Biological Process	GO:0003281	ventricular septum development	Mdm4	IGI	MGI:MGI:96952	Mouse	PMID:22821713

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern