Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MCPH1
  • Mouse genes Mcph1
  • Rat genes Mcph1
  • Zfish genes mcph1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mcph1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	MCPH1	IPI	UniProtKB:Q8NEM0	Human	PMID:18660752
Molecular Function	GO:0005515	protein binding	MCPH1	IPI	UniProtKB:Q01094	Human	PMID:18660752
Molecular Function	GO:0005515	protein binding	MCPH1	IPI	UniProtKB:Q15554	Human	PMID:19287395
Biological Process	GO:0060348	bone development	Mcph1	IMP	MGI:MGI:4431685	Mouse	PMID:23516444
Biological Process	GO:0021987	cerebral cortex development	Mcph1	IMP	MGI:MGI:5308745	Mouse	PMID:21947081
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Mcph1	IMP	MGI:MGI:5308745	Mouse	PMID:21947081
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MCPH1	IDA		Human	PMID:12837246
Biological Process	GO:0097150	neuronal stem cell population maintenance	Mcph1	IMP	MGI:MGI:5308745	Mouse	PMID:21947081
Biological Process	GO:0071539	protein localization to centrosome	Mcph1	IMP	MGI:MGI:5308745	Mouse	PMID:21947081
Biological Process	GO:0046605	regulation of centrosome cycle	Mcph1	IMP	MGI:MGI:5308745	Mouse	PMID:21947081
Biological Process	GO:0060623	regulation of chromosome condensation	Mcph1	IMP	MGI:MGI:4332146	Mouse	PMID:20169082
Biological Process	GO:0010468	regulation of gene expression	Mcph1	IMP		Mouse	PMID:21737879
Biological Process	GO:0010468	regulation of gene expression	Mcph1	IGI	MGI:MGI:1202065	Mouse	PMID:21737879
Biological Process	GO:0050727	regulation of inflammatory response	Mcph1	IMP	MGI:MGI:4431685	Mouse	PMID:23516444
Biological Process	GO:0043549	regulation of kinase activity	Mcph1	IMP		Mouse	PMID:21737879

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern