Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MC1R
  • Mouse genes Mc1r
  • Rat genes
  • Zfish genes mc1r
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mc1r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004977	melanocortin receptor activity	Mc1r	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	MC1R	IPI	UniProtKB:P01189	Human	PMID:19743876
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	Mc1r	IDA		Mouse	PMID:9454589
Molecular Function	GO:0005515	protein binding	MC1R	IPI	UniProtKB:Q8TCY5	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MC1R	IPI	UniProtKB:Q96G30	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MC1R	IPI	UniProtKB:P01189	Human	PMID:19743876
Molecular Function	GO:0005515	protein binding	MC1R	IPI	UniProtKB:Q9H1Y3	Human	PMID:31097585
Molecular Function	GO:0005515	protein binding	Mc1r	IPI	PR:Q03288	Mouse	PMID:9454589
Molecular Function	GO:0005515	protein binding	mc1r	IPI	ZFIN:ZDB-GENE-100729-5	Zfish	PMID:24709359
Molecular Function	GO:0005515	protein binding	mc1r	IPI	ZFIN:ZDB-GENE-100729-3	Zfish	PMID:24709359
Molecular Function	GO:0031625	ubiquitin protein ligase binding	MC1R	IPI	UniProtKB:O60291	Human	PMID:19737927
Cellular Component	GO:0005886	plasma membrane	MC1R	IDA		Human	PMID:19452503
Cellular Component	GO:0005886	plasma membrane	MC1R	IDA		Human	PMID:31097585
Cellular Component	GO:0005886	plasma membrane	mc1r	IDA		Zfish	PMID:24709359
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	MC1R	IDA		Human	PMID:19329486
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	MC1R	IDA		Human	PMID:19743876
Biological Process	GO:0035556	intracellular signal transduction	Mc1r	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Biological Process	GO:0042438	melanin biosynthetic process	Mc1r	IMP	MGI:MGI:1856028	Mouse	PMID:7665913
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	MC1R	IMP		Human	PMID:10233018
Biological Process	GO:0043473	pigmentation	Mc1r	IMP	MGI:MGI:1856029	Mouse	MGI:MGI:87265
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	Mc1r	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Mc1r	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	Mc1r	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mc1r	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Biological Process	GO:0019233	sensory perception of pain	Mc1r	IMP	MGI:MGI:1856028	Mouse	PMID:12663858
Biological Process	GO:0070914	UV-damage excision repair	MC1R	IDA		Human	PMID:18292087

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern