Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP4K4
  • Mouse genes Map4k4
  • Rat genes Map4k4
  • Zfish genes map4k4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map4k4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MAP4K4	IDA		Human	PMID:9890973
Molecular Function	GO:0005524	ATP binding	Map4k4	IDA		Mouse	MGI:MGI:86683|PMID:9135144
Molecular Function	GO:0004111	creatine kinase activity	MAP4K4	IDA		Human	PMID:23207904
Molecular Function	GO:0008017	microtubule binding	MAP4K4	IDA		Human	PMID:25490267
Molecular Function	GO:0005515	protein binding	MAP4K4	IPI	UniProtKB:Q9H0R5	Human	PMID:12387898
Molecular Function	GO:0005515	protein binding	MAP4K4	IPI	UniProtKB:P10114	Human	PMID:14966141
Molecular Function	GO:0005515	protein binding	MAP4K4	IPI	UniProtKB:Q8N4C8	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	MAP4K4	IPI	UniProtKB:Q9NRI5	Human	PMID:29961565
Molecular Function	GO:0005515	protein binding	MAP4K4	IPI	UniProtKB:Q8N4C8	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Map4k4	IPI	UniProtKB:Q8R001	Mouse	MGI:MGI:6189265|PMID:25490267
Molecular Function	GO:0005515	protein binding	Map4k4	IPI	UniProtKB:P26038	Mouse	MGI:MGI:6093222|PMID:16938849
Molecular Function	GO:0005515	protein binding	Map4k4	IPI	UniProtKB:Q8R0S2	Mouse	MGI:MGI:6189265|PMID:25490267
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAP4K4	IDA		Human	PMID:9890973
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Map4k4	IDA		Mouse	MGI:MGI:86683|PMID:9135144
Cellular Component	GO:0005737	cytoplasm	MAP4K4	IDA		Human	PMID:14966141
Cellular Component	GO:0005925	focal adhesion	MAP4K4	IDA		Human	PMID:25490267
Cellular Component	GO:0005925	focal adhesion	Map4k4	IDA		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0035556	intracellular signal transduction	MAP4K4	IDA		Human	PMID:9890973
Biological Process	GO:0043066	negative regulation of apoptotic process	MAP4K4	IMP		Human	PMID:21196414
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Map4k4	IMP		Rat	PMID:19690174|RGD:7495848
Biological Process	GO:0010977	negative regulation of neuron projection development	Map4k4	IMP		Rat	PMID:18007665|RGD:2303352
Biological Process	GO:0070571	negative regulation of neuron projection regeneration	Map4k4	IMP		Rat	PMID:18007665|RGD:2303352
Biological Process	GO:0032014	positive regulation of ARF protein signal transduction	Map4k4	IMP		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0030335	positive regulation of cell migration	MAP4K4	IMP		Human	PMID:24163766
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	Map4k4	IMP		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0120183	positive regulation of focal adhesion disassembly	Map4k4	IMP		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0043547	positive regulation of GTPase activity	Map4k4	IMP		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0046330	positive regulation of JNK cascade	Map4k4	IDA		Mouse	MGI:MGI:86683|PMID:9135144
Biological Process	GO:0051549	positive regulation of keratinocyte migration	Map4k4	IMP		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0006468	protein phosphorylation	MAP4K4	IDA		Human	PMID:9890973
Biological Process	GO:0006468	protein phosphorylation	Map4k4	IDA		Mouse	MGI:MGI:86683|PMID:9135144
Biological Process	GO:0046328	regulation of JNK cascade	MAP4K4	IDA		Human	PMID:14966141

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern