Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MANF
  • Mouse genes Manf
  • Rat genes Manf
  • Zfish genes manf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Manf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MANF	IPI	UniProtKB:Q16799-3	Human	PMID:25543119
Molecular Function	GO:0003723	RNA binding	MANF	HDA		Human	PMID:22658674
Molecular Function	GO:0120146	sulfatide binding	MANF	IPI	CHEBI:18318	Human	PMID:29497057
Cellular Component	GO:0005783	endoplasmic reticulum	Manf	IDA		Rat	PMID:19641128|RGD:2325813
Cellular Component	GO:0005788	endoplasmic reticulum lumen	MANF	IDA		Human	PMID:29497057
Cellular Component	GO:0005615	extracellular space	Manf	IDA		Rat	PMID:19641128|RGD:2325813
Cellular Component	GO:0005634	nucleus	MANF	HDA		Human	PMID:21630459
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Manf	IDA		Rat	PMID:19641128|RGD:2325813
Biological Process	GO:0071542	dopaminergic neuron differentiation	manf	IMP	ZFIN:ZDB-MRPHLNO-121203-11,ZFIN:ZDB-MRPHLNO-121203-12	Zfish	PMID:22898306
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	MANF	IMP		Human	PMID:29497057
Biological Process	GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure	Manf	IDA		Mouse	PMID:18718866

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern