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Manf
Gene Detail
 Symbol
Name
ID
Manf
mesencephalic astrocyte-derived neurotrophic factor
MGI:1922090
Synonyms 3230402M22Rik, Armet
Feature Type protein coding gene
Genetic Map
Chromosome 9
57.98 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:106838312-106891979 bp, - strand
From VEGA annotation of GRCm38

  53668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4383  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Manf

Human
homologs
Human Homolog MANF, mesencephalic astrocyte-derived neurotrophic factor
NCBI Gene ID 7873
neXtProt AC  NX_P55145
Human Synonyms  ARMET, ARP
Human Chr (Location)  3p21.1; chr3:51385261-51389397 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(21) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Manf interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process response to unfolded protein, vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
Component extracellular region, nucleus
Function growth factor activity, poly(A) RNA binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 29
cDNA source data(194)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(198) Genomic(4) cDNA(194)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032651 (Evidence)
Ensembl Gene ModelENSMUSG00000032575 (Evidence)
Entrez Gene74840 (Evidence)
UniGene29778
DFCITC1572158, TC1592208
NIA Mouse Gene IndexU031310
PDB2RQY
Consensus CDS ProjectCCDS23486.1
International Mouse Knockout Project StatusManf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032651 VEGA Gene Model | MGI Sequence Detail 53668 C57BL/6J ±  kb
transcript OTTMUST00000077206 VEGA | MGI Sequence Detail 2247 Not Applicable 
polypeptide OTTMUSP00000040776 VEGA | MGI Sequence Detail 179 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(8)
Polymorphisms SNPs within 2kb(252 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019345 Armet protein
InterPro IPR011001 Saposin-like
Protein Ontology PR:000004300 protein ARMET
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGI:2142911, MGI:2142925, MGI:2154780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory