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Manf Gene Detail
Summary
  • Symbol
    Manf
  • Name
    mesencephalic astrocyte-derived neurotrophic factor
  • Synonyms
    3230402M22Rik, Armet
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922090
    NCBI Gene: 74840
  • Gene Overview
    MyGene.info: MANF
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:106838312-106891979 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      53668 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.98 cM, cytoband F1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MANF, mesencephalic astrocyte derived neurotrophic factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MANF, mesencephalic astrocyte derived neurotrophic factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARMET, ARP
  • Links
    NCBI Gene ID: 7873
    neXtProt AC: NX_P55145
    UniProt: P55145

  • Chr Location
    3p21.2; chr3:51385237-51389397 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 4383
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MANF
  • Gene Tree
    Manf
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous KO affects de novo protein synthesis in differentiating neuronal stem cells and pancreatic beta cells, disrupting the migration and neurite growth of developing cortical neurons and causing severe growth retardation and hyperglycemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    29
  • Tissues
    29
  • cDNA Data
    195
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032651 VEGA Gene Model | MGI Sequence Detail 53668 C57BL/6J ±  kb
    transcript OTTMUST00000077206 VEGA | MGI Sequence Detail 2247 Not Applicable  
    polypeptide OTTMUSP00000040776 VEGA | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      250 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 199
      Genomic 4
      cDNA 195

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142911, MGI:2142925, MGI:2154780
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:255942 Tseng KY, et al., MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex. eNeuro. 2017 Sep-Oct;4(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory