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Manf Gene Detail
Summary
  • Symbol
    Manf
  • Name
    mesencephalic astrocyte-derived neurotrophic factor
  • Synonyms
    3230402M22Rik, Armet
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922090
    NCBI Gene: 74840
  • Gene Overview
    MyGene.info: MANF
Location & Maps
more
  • Sequence Map
    Chr9:106838312-106891979 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      53668 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.98 cM, cytoband F1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MANF, mesencephalic astrocyte derived neurotrophic factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MANF, mesencephalic astrocyte derived neurotrophic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARMET, ARP
  • Links
    NCBI Gene ID: 7873
    neXtProt AC: NX_P55145

  • Chr Location
    3p21.1; chr3:51385237-51389397 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 4383
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MANF
  • Gene Tree
    Manf
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    23
  • Gene trapped
    21
  • Targeted
    2
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    29
  • Tissues
    29
  • cDNA Data
    194
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032651 VEGA Gene Model | MGI Sequence Detail 53668 C57BL/6J ±  kb
transcript OTTMUST00000077206 VEGA | MGI Sequence Detail 2247 Not Applicable  
polypeptide OTTMUSP00000040776 VEGA | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    250 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 198
    Genomic 4
    cDNA 194

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142911, MGI:2142925, MGI:2154780
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:211812 Lindahl M, et al., MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep. 2014 Apr 24;7(2):366-75
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory