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Manf Gene Detail
Summary
  • Symbol
    Manf
  • Name
    mesencephalic astrocyte-derived neurotrophic factor
  • Synonyms
    3230402M22Rik, Armet
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922090
    NCBI Gene: 74840
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106765952-106769137 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.98 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922090
 protein coding gene Chr9:106715511-106769178 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035245
 protein coding gene Chr9:108682559-108742228 (-)
A/J MGP_AJ_G0035224
 protein coding gene Chr9:104738594-104793279 (-)
AKR/J MGP_AKRJ_G0035156
 protein coding gene Chr9:107340517-107395628 (-)
BALB/cJ MGP_BALBcJ_G0035218
 protein coding gene Chr9:104420377-104473731 (-)
C3H/HeJ MGP_C3HHeJ_G0034928
 protein coding gene Chr9:107759224-107812800 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035738
 protein coding gene Chr9:111664054-111722906 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032636
 protein coding gene Chr9:102217705-102269064 (-)
CAST/EiJ MGP_CASTEiJ_G0034239
 protein coding gene Chr9:107685283-107739997 (-)
CBA/J MGP_CBAJ_G0034896
 protein coding gene Chr9:115641265-115700265 (-)
DBA/2J MGP_DBA2J_G0035057
 protein coding gene Chr9:104191257-104248152 (-)
FVB/NJ MGP_FVBNJ_G0035005
 protein coding gene Chr9:102977444-103031512 (-)
LP/J MGP_LPJ_G0035133
 protein coding gene Chr9:108892158-108947634 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035044
 protein coding gene Chr9:117197185-117254819 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035759
 protein coding gene Chr9:107612107-107675569 (-)
PWK/PhJ MGP_PWKPhJ_G0033946
 protein coding gene Chr9:104509415-104563936 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033781
 protein coding gene Chr9:107686658-107745220 (-)
WSB/EiJ MGP_WSBEiJ_G0034360
 protein coding gene Chr9:107517867-107573478 (-)



Homology
more
  • Human Ortholog
    MANF, mesencephalic astrocyte derived neurotrophic factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MANF, mesencephalic astrocyte derived neurotrophic factor
  • Synonyms
    ARMET, ARP, DDDS
  • Links
    NCBI Gene ID: 7873
    UniProt: P55145

  • Chr Location
    3p21.2; chr3:51385291-51389397 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human MANF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO affects de novo protein synthesis in differentiating neuronal stem cells and pancreatic beta cells, disrupting the migration and neurite growth of developing cortical neurons and causing severe growth retardation and hyperglycemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    121
  • cDNA Data
    196
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74840 NCBI Gene Model | MGI Sequence Detail 3186 C57BL/6J ±  kb
    transcript NM_029103 RefSeq | MGI Sequence Detail 868 ZRU/MplStud  
    polypeptide Q9CXI5 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 203
      Genomic 4
      cDNA 196
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142911, MGI:2142925, MGI:2154780
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 33
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:360064 Han D, et al., Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF-HSF1-HSP70-1 pathway: An effective treatment for hepatocellular carcinoma. Acta Pharm Sin B. 2024 Oct;14(10):4396-4412
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory