Manf
Gene Detail

Symbol

Name
ID

Manf
mesencephalic astrocyte-derived neurotrophic factor
MGI:1922090

Synonyms

3230402M22Rik, Armet

Feature Type

protein coding gene

Genetic Map

Chromosome 9
57.98 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:106838312-106891979 bp, - strand From VEGA annotation of GRCm38   53668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4383  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Manf

Human
homologs

Human Homolog		MANF, mesencephalic astrocyte-derived neurotrophic factor
NCBI Gene ID		7873
neXtProt AC		NX_P55145
Human Synonyms		ARMET, ARP
Human Chr (Location)		3p21.1; chr3:51385261-51389397 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(23) : Gene trapped(21) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Manf interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (6 annotations)

Process	response to unfolded protein, vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
Component	extracellular region, nucleus
Function	growth factor activity, poly(A) RNA binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (29)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	29

cDNA source data(194)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(198) Genomic(4) cDNA(194)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000032651 (Evidence)
Ensembl Gene Model	ENSMUSG00000032575 (Evidence)
Entrez Gene	74840 (Evidence)
UniGene	29778
DFCI	TC1592208, TC1572158
NIA Mouse Gene Index	U031310
PDB	2RQY
Consensus CDS Project	CCDS23486.1
International Mouse Knockout Project Status	Manf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032651	VEGA Gene Model | MGI Sequence Detail	53668	C57BL/6J
transcript	OTTMUST00000077206	VEGA | MGI Sequence Detail	2247	Not Applicable
polypeptide	OTTMUSP00000040776	VEGA | MGI Sequence Detail	179	Not Applicable

All sequences(67) RefSeq(4) UniProt(15)

Polymorphisms

SNPs within 2kb(252 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR019345	Armet protein
InterPro	IPR011001	Saposin-like
Protein Ontology	PR:000004300	protein ARMET

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211812 Lindahl M, et al., MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep. 2014 Apr 24;7(2):366-75
All references(41)

Other
accession IDs

MGI:2142911, MGI:2142925, MGI:2154780