Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MACROH2A2
  • Mouse genes Macroh2a2
  • Rat genes Macroh2a2
  • Zfish genes macroh2a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Macroh2a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	MACROH2A2	IDA		Human	PMID:19734898
Molecular Function	GO:0005515	protein binding	MACROH2A2	IPI	UniProtKB:P0C6X7:PRO_0000037315	Human	PMID:22046132
Molecular Function	GO:0005515	protein binding	MACROH2A2	IPI	UniProtKB:Q8N9E0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A2	IPI	UniProtKB:U3KQK0	Human	PMID:32296183
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MACROH2A2	IDA		Human	PMID:23595991
Molecular Function	GO:0000976	transcription cis-regulatory region binding	MACROH2A2	IDA		Human	PMID:19734898
Molecular Function	GO:0000976	transcription cis-regulatory region binding	macroh2a2	IDA		Zfish	PMID:19734898
Cellular Component	GO:0001740	Barr body	MACROH2A2	IDA		Human	PMID:11331621
Cellular Component	GO:0000785	chromatin	MACROH2A2	IDA		Human	PMID:19734898
Cellular Component	GO:0000785	chromatin	Macroh2a2	IDA		Rat	PMID:23463008|RGD:9588477
Cellular Component	GO:0000781	chromosome, telomeric region	MACROH2A2	HDA		Human	PMID:19135898
Cellular Component	GO:0070062	extracellular exosome	MACROH2A2	HDA		Human	PMID:23533145
Cellular Component	GO:0005654	nucleoplasm	MACROH2A2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Macroh2a2	IDA		Rat	PMID:23463008|RGD:9588477
Biological Process	GO:0007420	brain development	MACROH2A2	IMP		Human	PMID:19734898
Biological Process	GO:0007420	brain development	macroh2a2	IMP		Zfish	PMID:19734898|ZFIN:ZDB-PUB-090914-37
Biological Process	GO:0007549	dosage compensation	MACROH2A2	IDA		Human	PMID:11331621
Biological Process	GO:0071169	establishment of protein localization to chromatin	MACROH2A2	IMP		Human	PMID:19734898
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	MACROH2A2	IMP		Human	PMID:19734898
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MACROH2A2	IMP		Human	PMID:19734898
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Macroh2a2	IGI	MGI:MGI:1349392	Mouse	PMID:25312643
Biological Process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	MACROH2A2	IGI	UniProtKB:P0C0S8	Human	PMID:24071584
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	MACROH2A2	IMP		Human	PMID:23595991

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern