Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LTC4S
  • Mouse genes Ltc4s
  • Rat genes Ltc4s
  • Zfish genes ltc4s
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ltc4s

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043295	glutathione binding	Ltc4s	IDA		Rat	PMID:18440824|RGD:2316617
Molecular Function	GO:0042802	identical protein binding	LTC4S	IPI	UniProtKB:Q16873	Human	PMID:15530365
Molecular Function	GO:0042802	identical protein binding	LTC4S	IPI	UniProtKB:Q16873	Human	PMID:17632546
Molecular Function	GO:0042802	identical protein binding	LTC4S	IPI	UniProtKB:Q16873	Human	PMID:17632548
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	LTC4S	IDA		Human	PMID:8706658
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	LTC4S	IDA		Human	PMID:9153254
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	Ltc4s	IDA		Mouse	MGI:MGI:3028458|PMID:11319240
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	Ltc4s	IDA		Mouse	PMID:8706658
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	Ltc4s	IDA		Rat	PMID:12767051|RGD:724432
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	Ltc4s	IDA		Rat	PMID:17194456|RGD:1599839
Molecular Function	GO:0008289	lipid binding	LTC4S	IDA		Human	PMID:8706658
Molecular Function	GO:0008289	lipid binding	Ltc4s	IDA		Mouse	PMID:8706658
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:P09917	Human	PMID:19233132
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:P20292	Human	PMID:19233132
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:O14843	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:Q14802-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:Q8TBB6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTC4S	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0044877	protein-containing complex binding	Ltc4s	IPI	RGD:2097	Rat	PMID:15084748|RGD:2313918
Cellular Component	GO:0005783	endoplasmic reticulum	LTC4S	IDA		Human	PMID:19233132
Cellular Component	GO:0005789	endoplasmic reticulum membrane	LTC4S	IDA		Human	PMID:12023288
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Ltc4s	IDA		Rat	PMID:17194456|RGD:1599839
Cellular Component	GO:0005635	nuclear envelope	LTC4S	IDA		Human	PMID:19233132
Cellular Component	GO:0005635	nuclear envelope	LTC4S	IDA		Human	PMID:7599836
Cellular Component	GO:0031965	nuclear membrane	LTC4S	IDA		Human	PMID:12023288
Cellular Component	GO:0005640	nuclear outer membrane	LTC4S	IDA		Human	PMID:12023288
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ltc4s	IEP		Rat	PMID:9794912|RGD:2316634
Biological Process	GO:0071299	cellular response to vitamin A	Ltc4s	IEP		Rat	PMID:12767051|RGD:724432
Biological Process	GO:0019370	leukotriene biosynthetic process	Ltc4s	IDA		Rat	PMID:14637132|RGD:2302289
Biological Process	GO:0006691	leukotriene metabolic process	LTC4S	IDA		Human	PMID:8706658
Biological Process	GO:0006691	leukotriene metabolic process	LTC4S	IDA		Human	PMID:9153254
Biological Process	GO:0006691	leukotriene metabolic process	Ltc4s	IDA		Mouse	PMID:8706658
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process	LTC4S	IDA		Human	PMID:27791009
Biological Process	GO:0048678	response to axon injury	Ltc4s	IEP		Rat	PMID:19908283|RGD:2316612
Biological Process	GO:0010035	response to inorganic substance	Ltc4s	IEP		Rat	PMID:17496435|RGD:2302285
Biological Process	GO:0032496	response to lipopolysaccharide	Ltc4s	IEP		Rat	PMID:15619010|RGD:2316620
Biological Process	GO:0009410	response to xenobiotic stimulus	Ltc4s	IEP		Rat	PMID:12767051|RGD:724432

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern