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Ltc4s Gene Detail
Summary
  • Symbol
    Ltc4s
  • Name
    leukotriene C4 synthase
  • Feature Type
    protein coding gene
  • IDs
    MGI:107498
    NCBI Gene: 17001
  • Gene Overview
    MyGene.info: LTC4S
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:50236469-50238616 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2148 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 30.40 cM, cytoband B1.1-B1.2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LTC4S, leukotriene C4 synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LTC4S, leukotriene C4 synthase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4056
    neXtProt AC: NX_Q16873
    UniProt: Q16873

  • Chr Location
    5q35.3; chr5:179793985-179796512 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7406
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LTC4S
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormal inflammatory and hypersensitivity reactions but are otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005578 VEGA Gene Model | MGI Sequence Detail 2148 C57BL/6J ±  kb
    transcript OTTMUST00000012403 VEGA | MGI Sequence Detail 716 Not Applicable  
    polypeptide OTTMUSP00000005740 VEGA | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      12 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36066
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256646 Poczobutt JM, et al., Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15;196(2):891-901

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/03/2018
    MGI 6.12
    The Jackson Laboratory