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Ltc4s Gene Detail
Summary
  • Symbol
    Ltc4s
  • Name
    leukotriene C4 synthase
  • Feature Type
    protein coding gene
  • IDs
    MGI:107498
    NCBI Gene: 17001
Location & Maps
more
  • Sequence Map
    Chr11:50236469-50238616 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2148 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LTC4S, leukotriene C4 synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LTC4S, leukotriene C4 synthase
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 4056
    neXtProt AC: NX_Q16873

  • Chr Location
    5q35; chr5:179793985-179796512 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LTC4S associations

Human Disease Mouse Models
       Leukotriene C4 Synthase Deficiency   OMIM: 614037
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Ltc4s
  • Incidental Mutations
Mice homozygous for disruptions in this gene display abnormal inflammatory and hypersensitivity reactions but are otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005578 VEGA Gene Model | MGI Sequence Detail 2148 C57BL/6J ±  kb
transcript OTTMUST00000012403 VEGA | MGI Sequence Detail 716 Not Applicable  
polypeptide OTTMUSP00000005740 VEGA | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    7 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009977 leukotriene C4 synthase
  • PDB
  • EC
  • InterPro Domains
    IPR001446 5-lipoxygenase-activating protein
    IPR018295 FLAP/GST2/LTC4S, conserved site
    IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain
    IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Molecular
Reagents
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  • All nucleic 17
    Genomic 2
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36066
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:34202 Lam BK, et al., Molecular cloning, expression and characterization of mouse leukotriene C4 synthase. Eur J Biochem. 1996 Jun 15;238(3):606-12
  • Latest
    J:197334 Taketomi Y, et al., Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol. 2013 Jun;14(6):554-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory