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Ltc4s
Gene Detail
Symbol

Name
ID
Ltc4s
leukotriene C4 synthase
MGI:107498
Feature Type
protein coding gene
Genetic Map
Chromosome 11
30.40 cM, cytoband B1.1-B1.2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:50236469-50238616 bp, - strand
From VEGA annotation of GRCm38

  2148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7406  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: LTC4S
Gene Tree: Ltc4s

Human
homologs
LTC4S, leukotriene C4 synthase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4056
neXtProt AC: NX_Q16873

Human Chr (Location): 5q35; chr5:179793985-179796512 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LTC4S

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormal inflammatory and hypersensitivity reactions but are otherwise normal.
 
Interactions
Ltc4s interacts with 5 markers (Mir302b, Mir302c, Mir302d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process leukotriene biosynthetic process, leukotriene metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function enzyme activator activity, glutathione binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ltc4s.1, mgst2    NEW 
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(15)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005578 (Evidence)
Ensembl Gene Model ENSMUSG00000020377 (Evidence)
Entrez Gene 17001 (Evidence)
UniGene 245151
DFCI TC1650607, TC1586503, TC1592910
DoTS DT.94172476, DT.94172472, DT.530302
NIA Mouse Gene Index U032723
EC 4.4.1.20
PDB 4NTF, 4NTB, 4NTA
Consensus CDS Project CCDS24631.1
International Mouse Phenotyping Consortium Status Ltc4s
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005578 VEGA Gene Model | MGI Sequence Detail 2148 C57BL/6J ±  kb
transcript OTTMUST00000012403 VEGA | MGI Sequence Detail 716 Not Applicable 
polypeptide OTTMUSP00000005740 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001446 5-lipoxygenase-activating protein
InterPro IPR018295 FLAP/GST2/LTC4S, conserved site
InterPro IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain
InterPro IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Protein Ontology PR:000009977 leukotriene C4 synthase
References
(Earliest) J:34202 Lam BK, et al., Molecular cloning, expression and characterization of mouse leukotriene C4 synthase. Eur J Biochem. 1996 Jun 15;238(3):606-12
(Latest) J:197334 Taketomi Y, et al., Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol. 2013 Jun;14(6):554-63
All references(45)
Other
accession IDs
MGD-MRK-36066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory