Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRG1
  • Mouse genes Lrg1
  • Rat genes Lrg1
  • Zfish genes si:dkey-90m5.4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LRG1	IPI	UniProtKB:P17813	Human	PMID:23868260
Molecular Function	GO:0005515	protein binding	LRG1	IPI	UniProtKB:P17813-1	Human	PMID:23868260
Molecular Function	GO:0005515	protein binding	LRG1	IPI	UniProtKB:P36897-1	Human	PMID:23868260
Molecular Function	GO:0005515	protein binding	LRG1	IPI	UniProtKB:P37023	Human	PMID:23868260
Molecular Function	GO:0005515	protein binding	LRG1	IPI	UniProtKB:P37173-2	Human	PMID:23868260
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	Lrg1	IPI	PR:Q64729	Mouse	PMID:23868260
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	Lrg1	IPI	PR:Q62312	Mouse	PMID:23868260
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	Lrg1	IPI	PR:Q63961	Mouse	PMID:23868260
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	LRG1	IPI	UniProtKB:P36897	Human	PMID:23868260
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	LRG1	IPI	UniProtKB:P37023	Human	PMID:23868260
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	LRG1	IPI	UniProtKB:P37173	Human	PMID:23868260
Cellular Component	GO:0070062	extracellular exosome	LRG1	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	LRG1	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	LRG1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	LRG1	IDA		Human	PMID:20363744
Cellular Component	GO:0005615	extracellular space	Lrg1	IDA		Mouse	PMID:23868260
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	LRG1	IDA		Human	GO_REF:0000052
Biological Process	GO:0050873	brown fat cell differentiation	Lrg1	IDA		Mouse	PMID:18492766
Biological Process	GO:0051546	keratinocyte migration	LRG1	IMP		Human	PMID:32887674
Biological Process	GO:0051546	keratinocyte migration	Lrg1	IMP		Mouse	MGI:MGI:6489653|PMID:32887674
Biological Process	GO:0061756	leukocyte adhesion to vascular endothelial cell	LRG1	IMP		Human	PMID:32887674
Biological Process	GO:0061756	leukocyte adhesion to vascular endothelial cell	Lrg1	IMP		Mouse	MGI:MGI:6489653|PMID:32887674
Biological Process	GO:0045766	positive regulation of angiogenesis	LRG1	IMP		Human	PMID:32887674
Biological Process	GO:0045766	positive regulation of angiogenesis	LRG1	IMP		Human	PMID:23868260
Biological Process	GO:0045766	positive regulation of angiogenesis	Lrg1	IDA		Mouse	PMID:23868260
Biological Process	GO:0045766	positive regulation of angiogenesis	Lrg1	IMP	MGI:MGI:3797829	Mouse	PMID:23868260
Biological Process	GO:0045766	positive regulation of angiogenesis	Lrg1	IGI	MGI:MGI:95392	Mouse	PMID:23868260
Biological Process	GO:0045766	positive regulation of angiogenesis	Lrg1	IGI	MGI:MGI:98729	Mouse	PMID:23868260
Biological Process	GO:0045766	positive regulation of angiogenesis	Lrg1	IGI	MGI:MGI:1338946	Mouse	PMID:23868260
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	LRG1	IMP		Human	PMID:23868260
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Lrg1	IMP		Mouse	PMID:23868260
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	LRG1	IMP		Human	PMID:32887674
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	Lrg1	IMP		Mouse	MGI:MGI:6489653|PMID:32887674
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	LRG1	IDA		Human	PMID:32887674
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	LRG1	IMP		Human	PMID:32887674
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	Lrg1	IMP		Mouse	MGI:MGI:6489653|PMID:32887674
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	LRG1	IDA		Human	PMID:23868260
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	LRG1	IDA		Human	PMID:32887674
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Lrg1	IGI	MGI:MGI:98725	Mouse	PMID:23868260
Biological Process	GO:0009617	response to bacterium	Lrg1	IEP		Mouse	PMID:23012479
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	LRG1	IMP		Human	PMID:32887674
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	Lrg1	IMP		Mouse	MGI:MGI:6489653|PMID:32887674

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern