Lrg1 MGI Mouse Gene Detail - MGI:1924155 - leucine-rich alpha-2-glycoprotein 1

Symbol

Lrg1
Name

leucine-rich alpha-2-glycoprotein 1
Synonyms

1300008B03Rik, 2310031E04Rik, Lrhg

Feature Type

protein coding gene
IDs

MGI:1924155
NCBI Gene: 76905
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr17:56426678-56428946 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.17 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924155	protein coding gene	Chr17:56426678-56429001 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023914	protein coding gene	Chr17:57767108-57769374 (-)
A/J	MGP_AJ_G0023873	protein coding gene	Chr17:56209827-56212093 (-)
AKR/J	MGP_AKRJ_G0023843	protein coding gene	Chr17:56880750-56883016 (-)
BALB/cJ	MGP_BALBcJ_G0023875	protein coding gene	Chr17:56033118-56035384 (-)
C3H/HeJ	MGP_C3HHeJ_G0023638	protein coding gene	Chr17:57593564-57595830 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024319	protein coding gene	Chr17:60050076-60052342 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021766	protein coding gene	Chr17:52705705-52707971 (-)
CAST/EiJ	MGP_CASTEiJ_G0023121	protein coding gene	Chr17:57905431-57907698 (-)
CBA/J	MGP_CBAJ_G0023615	protein coding gene	Chr17:62348501-62350767 (-)
DBA/2J	MGP_DBA2J_G0023743	protein coding gene	Chr17:54925090-54927356 (-)
FVB/NJ	MGP_FVBNJ_G0023709	protein coding gene	Chr17:54445455-54447721 (-)
LP/J	MGP_LPJ_G0023823	protein coding gene	Chr17:58471587-58473850 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023736	protein coding gene	Chr17:61902037-61904303 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024364	protein coding gene	Chr17:57257280-57259546 (-)
PWK/PhJ	MGP_PWKPhJ_G0022866	protein coding gene	Chr17:54271528-54273796 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022678	protein coding gene	Chr17:54025202-54027463 (-)
WSB/EiJ	MGP_WSBEiJ_G0023185	protein coding gene	Chr17:57871302-57873568 (-)

Human Ortholog

LRG1, leucine rich alpha-2-glycoprotein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRG1, leucine rich alpha-2-glycoprotein 1
Synonyms

HMFT1766, LRG
Links

HGNC:29480

NCBI Gene ID: 116844

neXtProt AC: NX_P02750

UniProt: P02750
Chr Location

19p13.3; chr19:4537215-4540024 (-) GRCh38.p7

Alliance of Genome Resources

Lrg1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRG1
Gene Tree

Lrg1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a knock-out allele exhibit Tgfbr1-dependent increased growth of LCC tumor allografts.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

673
Tissues

1
cDNA Data

153
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PLIN5

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Lrg1 interacts with 29 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS28895.1

Ensembl

ENSMUSG00000037095 (Evidence)
NCBI Gene

76905

			Length	Strain/Species	Flank
genomic	76905	NCBI Gene Model \| MGI Sequence Detail	2269	C57BL/6J	± kb
transcript	NM_029796	RefSeq \| MGI Sequence Detail	1372	FVB/N
polypeptide	NP_084072	RefSeq \| MGI Sequence Detail	342	FVB/N

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UniProt

1 Sequence
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 153

cDNA 153

Microarray probesets 3

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MGI:1916869

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:322560 Dritsoula A, et al., Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Sci Rep. 2022 Mar 22;12(1):4867

TSS for Lrg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148762	Chr17:56428994-56429001 (-)	-52 bp
Tssr148761	Chr17:56428965-56428986 (-)	-30 bp
Tssr148760	Chr17:56428951-56428958 (-)	-9 bp
Tssr5175	Chr17:56428924-56428942 (-)	13 bp
Tssr148759	Chr17:56428897-56428920 (-)	37 bp
Tssr148758	Chr17:56428030-56428063 (-)	899 bp
Tssr148757	Chr17:56428010-56428028 (-)	927 bp
Tssr148756	Chr17:56427832-56427848 (-)	1,106 bp
Tssr148755	Chr17:56427793-56427818 (-)	1,140 bp
Tssr148754	Chr17:56427671-56427681 (-)	1,270 bp
Tssr148753	Chr17:56427613-56427620 (-)	1,329 bp
Tssr148752	Chr17:56427348-56427366 (-)	1,589 bp
Tssr148751	Chr17:56427293-56427314 (-)	1,642 bp
Tssr148750	Chr17:56427116-56427131 (-)	1,822 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/23/2022 MGI 6.20