Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LLGL2
  • Mouse genes Llgl2
  • Rat genes Llgl2
  • Zfish genes llgl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Llgl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030165	PDZ domain binding	LLGL2	IPI	UniProtKB:Q9BYG5	Human	PMID:12725730
Molecular Function	GO:0005515	protein binding	LLGL2	IPI	UniProtKB:P41743	Human	PMID:12725730
Molecular Function	GO:0005515	protein binding	LLGL2	IPI	UniProtKB:P81274	Human	PMID:15632202
Molecular Function	GO:0005515	protein binding	LLGL2	IPI	UniProtKB:P31016	Human	PMID:24513855
Molecular Function	GO:0005515	protein binding	LLGL2	IPI	UniProtKB:Q01650	Human	PMID:30996345
Cellular Component	GO:0005737	cytoplasm	LLGL2	IDA		Human	PMID:15632202
Cellular Component	GO:0005829	cytosol	LLGL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	LLGL2	IDA		Human	GO_REF:0000052
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	Llgl2	IMP	MGI:MGI:4331862	Mouse	PMID:21606200
Biological Process	GO:0030031	cell projection assembly	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:27249668
Biological Process	GO:0030031	cell projection assembly	llgl2	IGI	ZFIN:ZDB-GENE-011105-1	Zfish	PMID:27249668
Biological Process	GO:0007010	cytoskeleton organization	llgl2	IMP	ZFIN:ZDB-MRPHLNO-050817-1	Zfish	PMID:15983403
Biological Process	GO:0007010	cytoskeleton organization	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:15983403
Biological Process	GO:0008544	epidermis development	llgl2	IMP	ZFIN:ZDB-MRPHLNO-050817-1	Zfish	PMID:15983403
Biological Process	GO:0016332	establishment or maintenance of polarity of embryonic epithelium	Llgl2	IMP	MGI:MGI:4331862	Mouse	PMID:21606200
Biological Process	GO:0031581	hemidesmosome assembly	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:19911055
Biological Process	GO:0031581	hemidesmosome assembly	llgl2	IMP	ZFIN:ZDB-MRPHLNO-050817-1	Zfish	PMID:15983403
Biological Process	GO:0031581	hemidesmosome assembly	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:15983403
Biological Process	GO:0070121	Kupffer's vesicle development	llgl2	IMP	ZFIN:ZDB-MRPHLNO-050817-1	Zfish	PMID:23482490
Biological Process	GO:0070121	Kupffer's vesicle development	llgl2	IGI	ZFIN:ZDB-MRPHLNO-050817-1,ZFIN:ZDB-MRPHLNO-090617-5	Zfish	PMID:23482490
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Llgl2	IMP	MGI:MGI:4331862	Mouse	PMID:21606200
Biological Process	GO:0015820	leucine transport	LLGL2	IMP		Human	PMID:30996345
Biological Process	GO:0044458	motile cilium assembly	llgl2	IMP	ZFIN:ZDB-MRPHLNO-050817-1	Zfish	PMID:23482490
Biological Process	GO:0035264	multicellular organism growth	Llgl2	IMP	MGI:MGI:4331862	Mouse	PMID:21606200
Biological Process	GO:0030336	negative regulation of cell migration	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:15983403
Biological Process	GO:0008285	negative regulation of cell population proliferation	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:15983403
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:19911055
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:19911055
Biological Process	GO:0008594	photoreceptor cell morphogenesis	llgl2	IMP	ZFIN:ZDB-GENO-980202-996	Zfish	PMID:31015218
Biological Process	GO:0001890	placenta development	Llgl2	IMP	MGI:MGI:4331862	Mouse	PMID:21606200
Biological Process	GO:0009791	post-embryonic development	Llgl2	IMP	MGI:MGI:4331862	Mouse	PMID:21606200
Biological Process	GO:0048919	posterior lateral line neuromast development	llgl2	IMP	ZFIN:ZDB-MRPHLNO-100419-11,ZFIN:ZDB-MRPHLNO-100419-12	Zfish	PMID:19208766
Biological Process	GO:0045682	regulation of epidermis development	llgl2	IGI	ZFIN:ZDB-MRPHLNO-050817-1,ZFIN:ZDB-MRPHLNO-100510-12	Zfish	PMID:19570844
Biological Process	GO:0032878	regulation of establishment or maintenance of cell polarity	LLGL2	IDA		Human	PMID:12725730
Biological Process	GO:0043588	skin development	llgl2	IMP		Zfish	PMID:9007245
Biological Process	GO:0098773	skin epidermis development	llgl2	IGI	ZFIN:ZDB-GENO-151015-18,ZFIN:ZDB-MRPHLNO-050817-1	Zfish	PMID:26110643

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern