About   Help   FAQ
Llgl2 Gene Detail
Summary
  • Symbol
    Llgl2
  • Name
    LLGL2 scribble cell polarity complex component
  • Synonyms
    9130006H11Rik, MGC:27928
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918843
    NCBI Gene: 217325
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115824049-115855780 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918843
protein coding gene Chr11:115824029-115855780 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019402
protein coding gene Chr11:119894367-119930375 (+)
A/J MGP_AJ_G0019371
protein coding gene Chr11:114648136-114682857 (+)
AKR/J MGP_AKRJ_G0019341
protein coding gene Chr11:118071016-118102752 (+)
BALB/cJ MGP_BALBcJ_G0019345
protein coding gene Chr11:115066932-115098730 (+)
C3H/HeJ MGP_C3HHeJ_G0019151
protein coding gene Chr11:118418226-118453222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019795
protein coding gene Chr11:123556935-123588692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017418
protein coding gene Chr11:111671956-111706204 (+)
CAST/EiJ MGP_CASTEiJ_G0018706
protein coding gene Chr11:119759257-119795418 (+)
CBA/J MGP_CBAJ_G0019123
protein coding gene Chr11:128442788-128479638 (+)
DBA/2J MGP_DBA2J_G0019234
protein coding gene Chr11:114074169-114105958 (+)
FVB/NJ MGP_FVBNJ_G0019226
protein coding gene Chr11:113572094-113608112 (+)
LP/J MGP_LPJ_G0019304
protein coding gene Chr11:120275141-120312315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019259
protein coding gene Chr11:127555675-127592064 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019833
protein coding gene Chr11:118723406-118760080 (+)
PWK/PhJ MGP_PWKPhJ_G0018470
protein coding gene Chr11:115385711-115420773 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018263
protein coding gene Chr11:118470766-118506211 (+)
WSB/EiJ MGP_WSBEiJ_G0018758
protein coding gene Chr11:118684985-118723150 (+)



Homology
more
  • Human Ortholog
    LLGL2, LLGL scribble cell polarity complex component 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LLGL2, LLGL scribble cell polarity complex component 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HGL, Hugl-2, LGL2
  • Links
    NCBI Gene ID: 3993
    neXtProt AC: NX_Q6P1M3
    UniProt: Q6P1M3

  • Chr Location
    17q25.1; chr17:75525080-75575209 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele exhibit abnormal branching morphogenesis of the placental labyrinth layer and are born as runts but catch up in size by adulthood.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020782 Ensembl Gene Model | MGI Sequence Detail 31732 C57BL/6J ±  kb
    transcript ENSMUST00000177736 Ensembl | MGI Sequence Detail 3612 Not Applicable  
    polypeptide ENSMUSP00000136054 Ensembl | MGI Sequence Detail 1051 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR000664 Lethal(2) giant larvae protein
      IPR013577 Lethal giant larvae homologue 2
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR017986 WD40-repeat-containing domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:242842 Kharfallah F, et al., Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization. Hum Mol Genet. 2017 Jun 15;26(12):2307-2320

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory