About   Help   FAQ
Llgl2
Gene Detail
Symbol

Name
ID
Llgl2
lethal giant larvae homolog 2 (Drosophila)
MGI:1918843
Synonyms
9130006H11Rik, MGC:27928
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:115824049-115855780 bp, + strand
From VEGA annotation of GRCm38

  31732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LLGL2
Protein SuperFamily: lethal(2) giant larvae protein homolog 1/2
Gene Tree: Llgl2

Human
homologs
LLGL2, lethal giant larvae homolog 2 (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3993
neXtProt AC: NX_Q6P1M3

Human Synonyms: HGL, Hugl-2, LGL2

Human Chr (Location): 17q25.1; chr17:75525080-75575209 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(530) : Gene trapped(527) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Llgl2 interacts with 63 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function PDZ domain binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (85)    Tissues (12)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 85
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA LLGL2 ; Xenbase llgl2 ; ZFIN llgl2    NEW 
Molecular
reagents
All nucleic(96) cDNA(96)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000003613 (Evidence)
Ensembl Gene Model ENSMUSG00000020782 (Evidence)
Entrez Gene 217325 (Evidence)
UniGene 290450
DFCI TC1605427, TC1577308, TC1640522
DoTS DT.102545587, DT.40159175, DT.94341960
NIA Mouse Gene Index U013547
Consensus CDS Project CCDS25649.1, CCDS56820.1
International Mouse Phenotyping Consortium Status Llgl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003613 VEGA Gene Model | MGI Sequence Detail 31732 C57BL/6J ±  kb
transcript OTTMUST00000007781 VEGA | MGI Sequence Detail 3551 Not Applicable 
polypeptide OTTMUSP00000003783 VEGA | MGI Sequence Detail 1027 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(19) UniProt(9)
Polymorphisms
SNPs within 2kb(281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000664 Lethal(2) giant larvae protein
InterPro IPR013577 Lethal giant larvae homologue 2
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000009848 lethal(2) giant larvae protein homolog 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory