Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kras

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KRAS
- Mouse genes Kras
- Rat genes Kras
- Zfish genes kras
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kras

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	Kras	IDA		Rat	PMID:12594205\|RGD:1581766
Molecular Function	GO:0019002	GMP binding	Kras	IDA		Rat	PMID:12594205\|RGD:1581766
Molecular Function	GO:0003924	GTPase activity	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Molecular Function	GO:0030275	LRR domain binding	Kras	IDA		Rat	PMID:12594205\|RGD:1581766
Molecular Function	GO:0005515	protein binding	KRAS	IPI	UniProtKB:P50749	Human	PMID:12732644
Molecular Function	GO:0005515	protein binding	KRAS	IPI	UniProtKB:P52306	Human	PMID:24415755
Molecular Function	GO:0005515	protein binding	KRAS	IPI	UniProtKB:Q96II5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRAS	IPI	UniProtKB:P04049	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	KRAS	IPI	UniProtKB:P04049	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	KRAS	IPI	UniProtKB:Q99755	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	KRAS	IPI	UniProtKB:P04049	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	Kras	IPI	UniProtKB:Q01279	Mouse	MGI:MGI:5448104\|PMID:22975374
Molecular Function	GO:0005515	protein binding	Kras	IPI	UniProtKB:Q80UQ2	Mouse	MGI:MGI:4821068\|PMID:17404571
Molecular Function	GO:0005515	protein binding	Kras	IPI	UniProtKB:P04049	Mouse	MGI:MGI:5919143\|PMID:19164755
Molecular Function	GO:0005515	protein binding	Kras	IPI	UniProtKB:P04049	Mouse	MGI:MGI:5921590\|PMID:17229891
Molecular Function	GO:0005515	protein binding	Kras	IPI	UniProtKB:Q99N57	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Kras	IPI	UniProtKB:O08773	Rat	PMID:19319189\|RGD:8554645
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Kras	IDA		Mouse	PMID:12354753
Molecular Function	GO:0044877	protein-containing complex binding	KRAS	IDA		Human	PMID:23209302
Molecular Function	GO:0043495	protein-membrane adaptor activity	Kras	IDA		Mouse	PMID:12354753
Cellular Component	GO:0005737	cytoplasm	KRAS	IDA		Human	PMID:23698361
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	KRAS	IDA		Human	PMID:23698361
Cellular Component	GO:0005925	focal adhesion	KRAS	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	KRAS	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Kras	IDA		Mouse	PMID:10085069
Cellular Component	GO:0016020	membrane	Kras	IGI	MGI:MGI:1888594	Mouse	PMID:14966563
Cellular Component	GO:0045121	membrane raft	Kras	IDA		Rat	PMID:12594205\|RGD:1581766
Cellular Component	GO:0005739	mitochondrion	Kras	IDA		Rat	PMID:19616040\|RGD:2314839
Biological Process	GO:0030036	actin cytoskeleton organization	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Biological Process	GO:0060038	cardiac muscle cell proliferation	Kras	IEP		Rat	PMID:2447874\|RGD:151665807
Biological Process	GO:0008283	cell population proliferation	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Kras	IMP		Rat	PMID:14576830\|RGD:1600488
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	kras	IMP	ZFIN:ZDB-MRPHLNO-120911-3	Zfish	PMID:22302539
Biological Process	GO:0038002	endocrine signaling	Kras	IMP		Mouse	MGI:MGI:5607181\|PMID:25133424
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Kras	IGI	MGI:MGI:98371	Mouse	PMID:24058167
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Kras	IDA		Mouse	PMID:24058167
Biological Process	GO:0007565	female pregnancy	Kras	IEP		Rat	PMID:1570348\|RGD:11570399
Biological Process	GO:0021897	forebrain astrocyte development	Kras	IMP	MGI:MGI:2429948	Mouse	PMID:22577135
Biological Process	GO:0014009	glial cell proliferation	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Biological Process	GO:0007507	heart development	kras	IMP	ZFIN:ZDB-MRPHLNO-120911-3	Zfish	PMID:22302539
Biological Process	GO:0030097	hemopoiesis	kras	IMP	ZFIN:ZDB-MRPHLNO-090202-2	Zfish	PMID:18682746
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Kras	IGI	MGI:MGI:99511	Mouse	PMID:24675817
Biological Process	GO:0001889	liver development	Kras	IEP		Rat	PMID:1526114\|RGD:11060153
Biological Process	GO:0051450	myoblast proliferation	Kras	IEP		Rat	PMID:2425941\|RGD:151667421
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	Kras	IDA		Mouse	PMID:24058167
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Kras	IGI	MGI:MGI:97306	Mouse	PMID:10845775
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Kras	IGI	MGI:MGI:96224	Mouse	PMID:10845775
Biological Process	GO:0051402	neuron apoptotic process	Kras	IGI	MGI:MGI:96224	Mouse	PMID:10845775
Biological Process	GO:0051402	neuron apoptotic process	Kras	IGI	MGI:MGI:97306	Mouse	PMID:10845775
Biological Process	GO:0008284	positive regulation of cell population proliferation	KRAS	IMP		Human	PMID:23698361
Biological Process	GO:2000774	positive regulation of cellular senescence	Kras	IMP		Rat	PMID:17706954\|RGD:11060281
Biological Process	GO:0010628	positive regulation of gene expression	KRAS	IMP		Human	PMID:22065586
Biological Process	GO:0010628	positive regulation of gene expression	Kras	IMP	MGI:MGI:2429948	Mouse	PMID:22577135
Biological Process	GO:0060252	positive regulation of glial cell proliferation	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Kras	IMP		Rat	PMID:10969813\|RGD:1600497
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Kras	IMP		Rat	PMID:14576830\|RGD:1600488
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Kras	IMP		Rat	PMID:14576830\|RGD:1600488
Biological Process	GO:0001934	positive regulation of protein phosphorylation	KRAS	IMP		Human	PMID:22065586
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Biological Process	GO:0016601	Rac protein signal transduction	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Biological Process	GO:0007265	Ras protein signal transduction	Kras	IGI	MGI:MGI:97306	Mouse	PMID:15665300
Biological Process	GO:0007265	Ras protein signal transduction	Kras	IMP	MGI:MGI:2429948	Mouse	PMID:22577135
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Kras	IGI	MGI:MGI:97306	Mouse	PMID:11793011
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	Kras	IGI	MGI:MGI:97306	Mouse	PMID:11793011
Biological Process	GO:0051384	response to glucocorticoid	Kras	IEP		Rat	PMID:1420288\|RGD:1581770
Biological Process	GO:0051384	response to glucocorticoid	Kras	IEP		Rat	PMID:16543373\|RGD:1581767
Biological Process	GO:0009629	response to gravity	Kras	IEP		Rat	PMID:14638460\|RGD:151361116
Biological Process	GO:0035900	response to isolation stress	Kras	IEP		Rat	PMID:19616040\|RGD:2314839
Biological Process	GO:0051385	response to mineralocorticoid	Kras	IEP		Rat	PMID:16543373\|RGD:1581767
Biological Process	GO:0035914	skeletal muscle cell differentiation	Kras	IGI	MGI:MGI:97874	Mouse	PMID:15542848
Biological Process	GO:0051146	striated muscle cell differentiation	Kras	IGI	MGI:MGI:97874	Mouse	PMID:15542848
Biological Process	GO:0060509	type I pneumocyte differentiation	Kras	IDA		Mouse	PMID:24058167
Biological Process	GO:0008542	visual learning	Kras	IGI	MGI:MGI:97306	Mouse	PMID:11793011

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.