Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KMT2E
  • Mouse genes Kmt2e
  • Rat genes Kmt2e
  • Zfish genes kmt2e
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kmt2e

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	KMT2E	IPI	UniProtKB:O15294	Human	PMID:23629655
Molecular Function	GO:0019899	enzyme binding	KMT2E	IPI	UniProtKB:O15294,UniProtKB:Q93009	Human	PMID:26678539
Molecular Function	GO:0035064	methylated histone binding	KMT2E	IMP		Human	PMID:23798402
Molecular Function	GO:0035064	methylated histone binding	KMT2E	IDA		Human	PMID:24130829
Molecular Function	GO:0005515	protein binding	KMT2E	IPI	UniProtKB:P04637	Human	PMID:21423215
Molecular Function	GO:0005515	protein binding	KMT2E	IPI	UniProtKB:P51610	Human	PMID:23629655
Molecular Function	GO:0003713	transcription coactivator activity	KMT2E	IDA		Human	PMID:23629655
Cellular Component	GO:0000785	chromatin	KMT2E	IDA		Human	PMID:23798402
Cellular Component	GO:0000791	euchromatin	KMT2E	IDA		Human	PMID:23798402
Cellular Component	GO:0016604	nuclear body	KMT2E	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KMT2E	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KMT2E	IDA		Human	PMID:23629655
Cellular Component	GO:0005634	nucleus	KMT2E	IDA		Human	PMID:26678539
Cellular Component	GO:0032991	protein-containing complex	KMT2E	IDA		Human	PMID:23629655
Cellular Component	GO:0032991	protein-containing complex	KMT2E	IDA		Human	PMID:26678539
Biological Process	GO:0006306	DNA methylation	Kmt2e	IMP		Mouse	MGI:MGI:3834766|PMID:18854576
Biological Process	GO:0030218	erythrocyte differentiation	Kmt2e	IMP		Mouse	MGI:MGI:3834766|PMID:18854576
Biological Process	GO:0042119	neutrophil activation	Kmt2e	IMP		Mouse	MGI:MGI:3834766|PMID:18854576
Biological Process	GO:0002446	neutrophil mediated immunity	Kmt2e	IMP		Mouse	MGI:MGI:3834766|PMID:18854576
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KMT2E	IMP		Human	PMID:23629655
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	KMT2E	IMP		Human	PMID:23629655

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern