Kmt2e
Gene Detail

Symbol

Name
ID

Kmt2e
lysine (K)-specific methyltransferase 2E
MGI:1924825

Synonyms

1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5

Feature Type

protein coding gene

Genetic Map

Chromosome 5
10.33 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:23434441-23504235 bp, + strand From VEGA annotation of GRCm38   69795 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:18822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Kmt2e

Human
homologs

Human Homolog		KMT2E, lysine (K)-specific methyltransferase 2E
NCBI Gene ID		55904
neXtProt AC		NX_Q8IZD2
Human Synonyms		HDCMC04P, MLL5, NKp44L
Human Chr (Location)		7q22.1; chr7:105014190-105114085 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(62) : Gene trapped(57) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit neonatal and postnatal lethality, reduced fertility and growth, and abnormal lymphopoiesis.

 

Interactions

Kmt2e interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (29 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	intercellular bridge, intracellular membrane-bounded organelle, ...
Function	enzyme binding, histone-lysine N-methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (110)    Tissues (110)    Images (9)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	110

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(8)

Other database
links

VEGA Gene Model	OTTMUSG00000021312 (Evidence)
Ensembl Gene Model	ENSMUSG00000029004 (Evidence)
Entrez Gene	69188 (Evidence)
NIA Mouse Gene Index	U005347, U367647
EC	2.1.1.43
Consensus CDS Project	CCDS51430.1
International Mouse Knockout Project Status	Kmt2e

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021312	VEGA Gene Model | MGI Sequence Detail	69795	C57BL/6J
transcript	OTTMUST00000050528	VEGA | MGI Sequence Detail	7252	Not Applicable
polypeptide	OTTMUSP00000023599	VEGA | MGI Sequence Detail	1868	Not Applicable

All sequences(61) RefSeq(10) UniProt(4)

Polymorphisms

SNPs within 2kb(312 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001214	SET domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000010448	histone-lysine N-methyltransferase MLL5

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181000 Yap DB, et al., Mll5 is required for normal spermatogenesis. PLoS One. 2011;6(11):e27127
All references(45)

Other
accession IDs

MGI:1916438, MGI:1925809