About   Help   FAQ
Kmt2e
Gene Detail
 Symbol
Name
ID
Kmt2e
lysine (K)-specific methyltransferase 2E
MGI:1924825
Synonyms 1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5
Feature Type protein coding gene
Genetic Map
Chromosome 5
10.33 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:23434441-23504235 bp, + strand
From VEGA annotation of GRCm38

  69795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kmt2e

Human
homologs
Human Homolog KMT2E, lysine (K)-specific methyltransferase 2E
NCBI Gene ID 55904
neXtProt AC  NX_Q8IZD2
Human Synonyms  HDCMC04P, MLL5, NKp44L
Human Chr (Location)  7q22.1; chr7:105014190-105114085 (+)  GRCh38
Alleles
and
phenotypes
All alleles(62) : Gene trapped(57) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neonatal and postnatal lethality, reduced fertility and growth, and abnormal lymphopoiesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell cycle, cell cycle arrest, ...
Component MLL5-L complex, nucleus
Function enzyme binding, histone-lysine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (110)    Tissues (110)    Images (9)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 110
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000021312 (Evidence)
Ensembl Gene ModelENSMUSG00000029004 (Evidence)
Entrez Gene69188 (Evidence)
NIA Mouse Gene IndexU005347, U367647
EC2.1.1.43
Consensus CDS ProjectCCDS51430.1
International Mouse Knockout Project StatusKmt2e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021312 VEGA Gene Model | MGI Sequence Detail 69795 C57BL/6J ±  kb
transcript OTTMUST00000050528 VEGA | MGI Sequence Detail 7252 Not Applicable 
polypeptide OTTMUSP00000023599 VEGA | MGI Sequence Detail 1868 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(312 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001214 SET domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000010448 histone-lysine N-methyltransferase MLL5
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181000 Yap DB, et al., Mll5 is required for normal spermatogenesis. PLoS One. 2011;6(11):e27127
All references(45)
Other
accession IDs
MGI:1916438, MGI:1925809

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory