Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KMT2B
  • Mouse genes Kmt2b
  • Rat genes Kmt2b
  • Zfish genes kmt2ba,kmt2bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kmt2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	KMT2B	IMP		Human	PMID:17166833
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	KMT2B	IDA		Human	PMID:17500065
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Kmt2b	IDA		Mouse	PMID:33766931
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Kmt2b	IMP	MGI:MGI:3056522,MGI:MGI:3623309	Mouse	PMID:20808952
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:Q14686	Human	PMID:17021013
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:18840606
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:Q14686	Human	PMID:19047629
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:Q14686	Human	PMID:19433796
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:22266653
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:22665483
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:23995757
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:24788516
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:Q9UBL3-3	Human	PMID:26886794
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	KMT2B	IPI	UniProtKB:P61964	Human	PMID:28514442
Molecular Function	GO:0045322	unmethylated CpG binding	KMT2B	IDA		Human	PMID:29276034
Molecular Function	GO:0008270	zinc ion binding	KMT2B	IDA		Human	PMID:29276034
Cellular Component	GO:0035097	histone methyltransferase complex	KMT2B	IDA		Human	PMID:17500065
Cellular Component	GO:0044665	MLL1/2 complex	KMT2B	IPI		Human	PMID:23508102
Cellular Component	GO:0005634	nucleus	KMT2B	IDA		Human	PMID:17500065
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	Kmt2b	IMP	MGI:MGI:3056522,MGI:MGI:3623309	Mouse	PMID:20808952
Biological Process	GO:0160021	maternal-to-zygotic transition of gene expression	Kmt2b	IMP	MGI:MGI:3056522,MGI:MGI:3623309	Mouse	PMID:20808952
Biological Process	GO:0160021	maternal-to-zygotic transition of gene expression	Kmt2b	IMP	MGI:MGI:2176052,MGI:MGI:3623309	Mouse	PMID:20808952
Biological Process	GO:0048599	oocyte development	Kmt2b	IMP	MGI:MGI:3056522,MGI:MGI:3623309	Mouse	PMID:20808952
Biological Process	GO:0001541	ovarian follicle development	Kmt2b	IMP	MGI:MGI:2176052,MGI:MGI:3623309	Mouse	PMID:20808952
Biological Process	GO:0001541	ovarian follicle development	Kmt2b	IMP	MGI:MGI:3056522,MGI:MGI:3623309	Mouse	PMID:20808952
Biological Process	GO:0030728	ovulation	Kmt2b	IMP	MGI:MGI:3056522,MGI:MGI:3623309	Mouse	PMID:20808952
Biological Process	GO:0030728	ovulation	Kmt2b	IMP	MGI:MGI:2176052,MGI:MGI:3623309	Mouse	PMID:20808952

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern