Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLK5
  • Mouse genes Klk5
  • Rat genes Klk5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klk5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008233	peptidase activity	KLK5	IMP		Human	PMID:17012259
Molecular Function	GO:0005515	protein binding	KLK5	IPI	UniProtKB:Q5DT21	Human	PMID:19194479
Molecular Function	GO:0005515	protein binding	KLK5	IPI	UniProtKB:P20930	Human	PMID:23629652
Molecular Function	GO:0005515	protein binding	KLK5	IPI	UniProtKB:Q9NQG1	Human	PMID:32296183
Molecular Function	GO:0004252	serine-type endopeptidase activity	KLK5	EXP		Human	PMID:16885167
Molecular Function	GO:0004252	serine-type endopeptidase activity	KLK5	IDA		Human	PMID:16885167
Cellular Component	GO:0097209	epidermal lamellar body	KLK5	IDA		Human	PMID:15675955
Cellular Component	GO:0005615	extracellular space	KLK5	IMP		Human	PMID:17012259
Biological Process	GO:0002803	positive regulation of antibacterial peptide production	KLK5	IMP		Human	PMID:17012259
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	KLK5	IDA		Human	PMID:16885167

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern